Itch, sleep loss, depressive symptoms, fatigue, and productivity loss in patients with moderate-to-severe atopic dermatitis: Analyses of TREATgermany registry data

Birkner T, Siegels D, Heinrich L, Haufe E, Abraham S, Heratizadeh A, Harder I, Bell M, Fell I, Worm M, Handrick C, Effendy I, Asmussen A, Kleinheinz A, Homey B, Sticherling M, Hong-Weldemann SH, Augustin M, Weisshaar E, Schäkel K, Schaefer T, Schwarz B, Wiemers F, Brücher JJ, Quist S, Wollenberg A, Biedermann T, Ertner K, von Kiedrowski R, Werfel T, Weidinger S, Schmitt J (2023)

Publication Type: Journal article

Publication year: 2023

Journal

DOI: 10.1111/ddg.15159

Abstract

Background: TREATgermany is a multicenter registry including patients with moderate-to-severe atopic dermatitis (AD) from currently 74 study centers (university clinics, hospitals and practices) in Germany. As of August 31, 2021, 1,230 adult patients were enrolled. Methods: In TREATgermany, patients and physicians fill in questionnaires pertaining to symptoms, disease severity, quality of life, depressiveness, and fatigue. In particular, limitations in work performance are assessed using the Work Limitations Questionnaire (WLQ). To assess associations between occupational performance/work limitations and symptoms, correlations and regression models were calculated. Results: The examined sample of 228 employed patients reported an average of 6% at-work productivity loss within the past two weeks prior to enrolment in the registry. The WLQ productivity loss score was moderately associated with itch (r = 0.32) and sleep loss (r = 0.39) and strongly associated with depressive symptoms (r = 0.68) and fatigue (r = 0.60). Conclusions: The analyses of the registry data show that moderate-to-severe atopic dermatitis has a negative impact on the work productivity of the patients. The analyses further point out the relevant associations between work productivity, depressive symptoms, and fatigue highlighting the disease burden caused by the psychological components of AD.

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Additional Organisation(s)

Involved external institutions

Universitätsklinikum Carl Gustav Carus Dresden Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) Germany (DE) Ruprecht-Karls-Universität Heidelberg Germany (DE) Universitätsklinikum Heidelberg Germany (DE) Hautmedizin Bad Soden Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Universität Bielefeld Germany (DE) Elbe Kliniken Stade-Buxtehude Germany (DE) Universitätsklinikum Düsseldorf Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Media Seasons - Steffen Kleinke & Ronny Burkersroda GbR Germany (DE) Helix Mainz GmbH & Co. KG Germany (DE) Universitair Ziekenhuis Brussel Belgium (BE) Technische Universität München (TUM) Germany (DE)

How to cite

APA:

Birkner, T., Siegels, D., Heinrich, L., Haufe, E., Abraham, S., Heratizadeh, A.,... Schmitt, J. (2023). Itch, sleep loss, depressive symptoms, fatigue, and productivity loss in patients with moderate-to-severe atopic dermatitis: Analyses of TREATgermany registry data. Journal der Deutschen Dermatologischen Gesellschaft. https://doi.org/10.1111/ddg.15159

MLA:

Birkner, Thomas, et al. "Itch, sleep loss, depressive symptoms, fatigue, and productivity loss in patients with moderate-to-severe atopic dermatitis: Analyses of TREATgermany registry data." Journal der Deutschen Dermatologischen Gesellschaft (2023).

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