Laser-Activated Self-Assembled Thermoplasmonic Nanocavity Substrates for Intracellular Delivery

Madrid M, Saklayen N, Shen W, Huber M, Vogel N, Mazur E (2018)

Publication Type: Journal article

Publication year: 2018

Journal

ACS Applied Bio Materials American Chemical Society

Book Volume: 1

Pages Range: 1793-1799

Journal Issue: 6

DOI: 10.1021/acsabm.8b00447

Abstract

Intracellular delivery is crucial for cellular engineering and the development of therapeutics. Laser-activated thermoplasmonic nanostructured surfaces are a promising platform for high-efficiency, high-viability, high-throughput intracellular delivery. Their fabrication, however, typically involves complicated nanofabrication techniques, limiting the approach's applicability. Here, colloidal self-assembly and templating are used to fabricate large arrays of thermoplasmonic nanocavities simply and cost-effectively. These laser-activated substrates are used to deliver membrane-impermeable dye into cells at an efficiency of 78% and throughput of 30â»000 cells min-1 while maintaining 87% cell viability. Proof-of-concept data show delivery of large cargoes ranging from 0.6 to 2000 kDa to cells without compromising viability.

Authors with CRIS profile

Nicolas Vogel Professur für Partikelsynthese

Involved external institutions

Harvard University US United States (USA) (US) Ludwig-Maximilians-Universität (LMU) DE Germany (DE)

How to cite

APA:

Madrid, M., Saklayen, N., Shen, W., Huber, M., Vogel, N., & Mazur, E. (2018). Laser-Activated Self-Assembled Thermoplasmonic Nanocavity Substrates for Intracellular Delivery. ACS Applied Bio Materials, 1(6), 1793-1799. https://doi.org/10.1021/acsabm.8b00447

MLA:

Madrid, Marinna, et al. "Laser-Activated Self-Assembled Thermoplasmonic Nanocavity Substrates for Intracellular Delivery." ACS Applied Bio Materials 1.6 (2018): 1793-1799.

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