Stem-cell-like properties and epithelial plasticity arise as stable traits after transient twist1 activation

Schmidt JM, Panzilius E, Bartsch HS, Irmler M, Beckers J, Kari V, Linnemann JR, Dragoi D, Hirschi B, Kloos UJ, Sass S, Theis F, Kahlert S, Johnsen SA, Sotlar K, Scheel CH (2015)


Publication Type: Journal article

Publication year: 2015

Journal

Book Volume: 10

Pages Range: 131-139

Journal Issue: 2

DOI: 10.1016/j.celrep.2014.12.032

Abstract

Master regulators of the epithelial-mesenchymal transition such as Twist1 and Snail1 have been implicated in invasiveness and the generation of cancer stem cells, but their persistent activity inhibitsstem-cell-like properties and the outgrowth of disseminated cancer cells into macroscopic metastases. Here, we show that Twist1 activation primes a subset of mammary epithelial cells for stem-cell-like properties, which only emerge and stably persist following Twist1 deactivation. Consequently, when cells undergo a mesenchymal-epithelial transition (MET), they do not return to their original epithelial cell state, evidenced by acquisition of invasive growth behavior and a distinct gene expression profile. These data provide an explanation for how transient Twist1 activation may promote all steps ofthe metastatic cascade; i.e., invasion, dissemination, and metastatic outgrowth at distant sites.

Involved external institutions

How to cite

APA:

Schmidt, J.M., Panzilius, E., Bartsch, H.S., Irmler, M., Beckers, J., Kari, V.,... Scheel, C.H. (2015). Stem-cell-like properties and epithelial plasticity arise as stable traits after transient twist1 activation. Cell Reports, 10(2), 131-139. https://doi.org/10.1016/j.celrep.2014.12.032

MLA:

Schmidt, Johanna M., et al. "Stem-cell-like properties and epithelial plasticity arise as stable traits after transient twist1 activation." Cell Reports 10.2 (2015): 131-139.

BibTeX: Download