Myocardial strain computed at multiple spatial scales from tagged magnetic resonance imaging: Estimating cardiac biomarkers for CRT patients
Sinclair M, Peressutti D, Puyol-Anton E, Bai W, Rivolo S, Webb J, Claridge S, Jackson T, Nordsletten D, Hadjicharalambous M, Kerfoot E, Rinaldi CA, Rueckert D, King AP (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 43
Pages Range: 1339-1351
DOI: 10.1016/j.media.2017.10.004
Abstract
Abnormal cardiac motion can indicate different forms of disease, which can manifest at different spatial scales in the myocardium. Many studies have sought to characterise particular motion abnormalities associated with specific diseases, and to utilise motion information to improve diagnoses. However, the importance of spatial scale in the analysis of cardiac deformation has not been extensively investigated. We build on recent work on the analysis of myocardial strains at different spatial scales using a cardiac motion atlas to find the optimal scales for estimating different cardiac biomarkers. We apply a multi-scale strain analysis to a 43 patient cohort of cardiac resynchronisation therapy (CRT) patients using tagged magnetic resonance imaging data for (1) predicting response to CRT, (2) identifying septal flash, (3) estimating QRS duration, and (4) identifying the presence of ischaemia. A repeated, stratified cross-validation is used to demonstrate the importance of spatial scale in our analysis, revealing different optimal spatial scales for the estimation of different biomarkers.
Involved external institutions
King’s College London
United Kingdom (GB)
Imperial College London / The Imperial College of Science, Technology and Medicine
United Kingdom (GB)
United Kingdom (GB)
Imperial College London / The Imperial College of Science, Technology and Medicine
United Kingdom (GB)
How to cite
APA:
Sinclair, M., Peressutti, D., Puyol-Anton, E., Bai, W., Rivolo, S., Webb, J.,... King, A.P. (2018). Myocardial strain computed at multiple spatial scales from tagged magnetic resonance imaging: Estimating cardiac biomarkers for CRT patients. Medical Image Analysis, 43, 1339-1351. https://doi.org/10.1016/j.media.2017.10.004
MLA:
Sinclair, Matthew, et al. "Myocardial strain computed at multiple spatial scales from tagged magnetic resonance imaging: Estimating cardiac biomarkers for CRT patients." Medical Image Analysis 43 (2018): 1339-1351.
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