Spectral-detector based x-ray absorptiometry (SDXA): In-vivo bone mineral density measurements in patients with and without osteoporotic fractures

Laugerette A, Baum T, Gersing AS, Schwaiger BJ, Brown K, Frerking LC, Shapira N, Pfeiffer D, Rummeny EJ, Proksa R, Pfeiffer F, Noel PB (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Biomedical Physics and Engineering Express IOP Publishing: Hybrid Open Access

Book Volume: 6

Article Number: 055021

Journal Issue: 5

DOI: 10.1088/2057-1976/abab6b

Abstract

Objectives: To study whether a dual-layer spectral CTscout scan-based arealBMDestimation method, called Spectral-detector based x-ray absorptiometry (SDXA), can differentiate patients with versus without osteoporotic fractures. Methods: The ability of the method to differentiate patients with osteoporosis was evaluated by assessing the arealBMDat the spine (L1 to L4) in a group of 19 patients presenting at least one fracture and comparing these results to the arealBMDof age- and gendermatched controls (57 patients). Finally, the reproducibility of SDXA was evaluated in-vivo through the calculation of coefficients of variation (CV), using three repeated analyses performed on each patient. Results: The average arealBMDof patients presenting fractures, measured with the scout scan-based method (0.86±0.17 g cm-2), was found to be significantly lower than the average BMD of the control group (1.00±0.17 g cm-2, p=0.043). The reproducibility of the method in-vivo was found to be reasonable, with CVs ranging between 3.1 and 6.9%. Conclusions: The results illustrate that the SDXA method for DXA-equivalent areal BMD estimation -delivers the ability to distinguish patients presenting osteoporotic fractures. Considering the total number of CT examinations worldwide, SDXA could develop to be a useful tool for truly opportunistic osteoporosis screening for a future clinical day-to-day routine.

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) Philips Medical Systems MR Finland FI Finland (FI) Philips Deutschland GmbH DE Germany (DE) University of Pennsylvania US United States (USA) (US)

How to cite

APA:

Laugerette, A., Baum, T., Gersing, A.S., Schwaiger, B.J., Brown, K., Frerking, L.C.,... Noel, P.B. (2020). Spectral-detector based x-ray absorptiometry (SDXA): In-vivo bone mineral density measurements in patients with and without osteoporotic fractures. Biomedical Physics and Engineering Express, 6(5). https://doi.org/10.1088/2057-1976/abab6b

MLA:

Laugerette, Alexis, et al. "Spectral-detector based x-ray absorptiometry (SDXA): In-vivo bone mineral density measurements in patients with and without osteoporotic fractures." Biomedical Physics and Engineering Express 6.5 (2020).

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