Mesoporous additive-free vaterite CaCO3 crystals of untypical sizes: From submicron to Giant
Vikulina AS, Webster J, Voronin D, Ivanov E, Fakhrullin R, Vinokurov V, Volodkin D (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 197
Article Number: 109220
DOI: 10.1016/j.matdes.2020.109220
Abstract
Mesoporous CaCO3 crystals of sizes in the range 3–15 μm have attracted significant scientific attention as fully decomposable biocompatible drug delivery vectors. They are also used as sacrificial templates to produce polymer-based microcarriers (capsules, beads) and polymer scaffolds for tissue engineering at biologically friendly conditions. However, fabrication of CaCO3 crystals with the sizes beyond the conventional range without additives is still a challenge. There is a desperate need of sub-micrometre and sub-millimetre biocompatible and easily decomposable vectors for intracellular delivery and design of tailor-made polymer scaffolds, respectively. In this study, additive-free one-step fabrication of vaterite mesoporous crystals with sizes in the range from submicron (0.72 μm) up to tens of microns (55 μm) sizes is proposed. Crystals are grown by mixing of Ca2+ and CO32− salts in aqueous media. Internal structure and morphology of the crystals have been investigated. Encapsulation of lysozyme by means of co-synthesis shows an enhanced entrapment into submicron crystals. Besides, the approach to grow CaCO3 crystals on the surface of microcellulose ьш is demonstrated opening broad avenues for the development of vaterite coatings technologies.
Authors with CRIS profile
Involved external institutions
Gubkin Russian State University of Oil and Gas
Russian Federation (RU)
Nottingham Trent University
United Kingdom (GB)
Fraunhofer-Institut für Zelltherapie und Immunologie (IZI)
Germany (DE)
Russian Federation (RU)
Nottingham Trent University
United Kingdom (GB)
Fraunhofer-Institut für Zelltherapie und Immunologie (IZI)
Germany (DE)
How to cite
APA:
Vikulina, A.S., Webster, J., Voronin, D., Ivanov, E., Fakhrullin, R., Vinokurov, V., & Volodkin, D. (2021). Mesoporous additive-free vaterite CaCO3 crystals of untypical sizes: From submicron to Giant. Materials & Design, 197. https://doi.org/10.1016/j.matdes.2020.109220
MLA:
Vikulina, Anna S., et al. "Mesoporous additive-free vaterite CaCO3 crystals of untypical sizes: From submicron to Giant." Materials & Design 197 (2021).
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