Interaction of the mechano-electrical feedback with passive mechanical models on a 3D rat left ventricle: a computational study

Journal article
(Review article)


Publication Details

Author(s): Duong MT, Holz D, Alkassar M, Dittrich S, Leyendecker S
Journal: Frontiers in Physiology
Publication year: 2019
Volume: 10
Pages range: 10-41
ISSN: 1664-042X


Abstract

In this paper, we are investigating the interaction between different passive material models
and the mechano-electrical feedback (MEF) in cardiac modelling. Various types of
passive mechanical laws (nearly incompressible/compressible, polynomial/exponential-type,
transversally isotropic/orthotropic material models) are integrated in a fully coupled electromechanical
model in order to study their specific influence on the overall MEF behaviour.
Our computational model is based on a three-dimensional (3D) geometry of a
healthy rat left ventricle reconstructed from magnetic resonance imaging (MRI). The electromechanically
coupled problem is solved using a fully implicit finite element-based approach.
The effects of different passive material models on the MEF are studied with the
help of numerical examples. It turns out that there is a significant difference between the
behaviour of the MEF for compressible and incompressible material models. Numerical results
for the incompressible models exhibit that a change in the electrophysiology can be
observed such that the transmembrane potential (TP) is unable to reach the resting state in
the repolarisation phase and this leads to non-zero relaxation deformations. The most significant
and strongest effects of the MEF on the rat cardiac muscle response are observed
for the exponential passive material law.


FAU Authors / FAU Editors

Dittrich, Sven Prof. Dr.
Professur für Kinderkardiologie
Duong, Minh Tuan Dr.-Ing.
Chair of Applied Dynamics
Holz, David
Chair of Applied Dynamics
Leyendecker, Sigrid Prof. Dr.-Ing.
Chair of Applied Dynamics


Additional Organisation
Chair of Applied Dynamics
Kinderkardiologische Abteilung in der Kinder- und Jugendklinik


Research Fields

biomechanics
Chair of Applied Dynamics
Modellierung/Simulation/Optimierung
Research focus area of a faculty: Technische Fakultät
Medizintechnik
Research focus area of a faculty: Technische Fakultät


How to cite

APA:
Duong, M.T., Holz, D., Alkassar, M., Dittrich, S., & Leyendecker, S. (2019). Interaction of the mechano-electrical feedback with passive mechanical models on a 3D rat left ventricle: a computational study. Frontiers in Physiology, 10, 10-41. https://dx.doi.org/10.3389/fphys.2019.01041

MLA:
Duong, Minh Tuan, et al. "Interaction of the mechano-electrical feedback with passive mechanical models on a 3D rat left ventricle: a computational study." Frontiers in Physiology 10 (2019): 10-41.

BibTeX: 

Last updated on 2019-12-08 at 10:38