Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia

Voelkl J, Lang F, Eckardt KU, Amann KU, Kuro-o M, Pasch A, Pieske B, Alesutan I (2019)

Publication Type: Journal article, Review article

Publication year: 2019

Journal

Cellular and Molecular Life Sciences Springer Verlag (Germany)

DOI: 10.1007/s00018-019-03054-z

Abstract

Medial vascular calcification has emerged as a putative key factor contributing to the excessive cardiovascular mortality of patients with chronic kidney disease (CKD). Hyperphosphatemia is considered a decisive determinant of vascular calcification in CKD. A critical role in initiation and progression of vascular calcification during elevated phosphate conditions is attributed to vascular smooth muscle cells (VSMCs), which are able to change their phenotype into osteo-/chondroblasts-like cells. These transdifferentiated VSMCs actively promote calcification in the medial layer of the arteries by producing a local pro-calcifying environment as well as nidus sites for precipitation of calcium and phosphate and growth of calcium phosphate crystals. Elevated extracellular phosphate induces osteo-/chondrogenic transdifferentiation of VSMCs through complex intracellular signaling pathways, which are still incompletely understood. The present review addresses critical intracellular pathways controlling osteo-/chondrogenic transdifferentiation of VSMCs and, thus, vascular calcification during hyperphosphatemia. Elucidating these pathways holds a significant promise to open novel therapeutic opportunities counteracting the progression of vascular calcification in CKD.

Authors with CRIS profile

Kerstin Ute Amann Department of Nephropathology

Involved external institutions

Johannes Kepler Universität (JKU) Linz AT Austria (AT) Eberhard Karls Universität Tübingen DE Germany (DE) Berliner Institut für Gesundheitsforschung (BIH) DE Germany (DE) Jichi Medical University / 自治医科大学 JP Japan (JP) Calciscon AG CH Switzerland (CH)

How to cite

APA:

Voelkl, J., Lang, F., Eckardt, K.U., Amann, K.U., Kuro-o, M., Pasch, A.,... Alesutan, I. (2019). Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-019-03054-z

MLA:

Voelkl, Jakob, et al. "Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia." Cellular and Molecular Life Sciences (2019).

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