Apolipoprotein A-I Mimetic Peptide L-4F Removes Bruch's Membrane Lipids in Aged Nonhuman Primates

Rudolf M, Curcio CA, Schlötzer-Schrehardt U, Sefat AMM, Tura A, Aherrahrou Z, Brinkmann M, Grisanti S, Miura Y, Ranjbar M (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Investigative Ophthalmology & Visual Science Association for Research in Vision and Ophthalmology (ARVO)

Book Volume: 60

Pages Range: 461-472

Journal Issue: 2

DOI: 10.1167/iovs.18-25786

Abstract

PURPOSE. Multiple evidence lines support Bruch's membrane lipid deposition as a major precursor of soft drusen and age-related macular degeneration as including a potentially treatable atherosclerosis-like progression in the subretinal pigment epithelium (RPE)-basal lamina space. We evaluated the effect of anti-inflammatory, antiatherogenic peptide L-4F on Bruch's membrane of aged nonhuman primates in a dose-escalating study.

Authors with CRIS profile

Ursula Schlötzer-Schrehardt Medizinische Fakultät

Involved external institutions

Universität zu Lübeck DE Germany (DE) University of Alabama at Birmingham (UAB) US United States (USA) (US)

How to cite

APA:

Rudolf, M., Curcio, C.A., Schlötzer-Schrehardt, U., Sefat, A.M.M., Tura, A., Aherrahrou, Z.,... Ranjbar, M. (2019). Apolipoprotein A-I Mimetic Peptide L-4F Removes Bruch's Membrane Lipids in Aged Nonhuman Primates. Investigative Ophthalmology & Visual Science, 60(2), 461-472. https://doi.org/10.1167/iovs.18-25786

MLA:

Rudolf, Martin, et al. "Apolipoprotein A-I Mimetic Peptide L-4F Removes Bruch's Membrane Lipids in Aged Nonhuman Primates." Investigative Ophthalmology & Visual Science 60.2 (2019): 461-472.

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