A new method to reduce false positive results in breast MRI by evaluation of multiple spectral regions in proton MR-spectroscopy
Clauser P, Marcon M, Dietzel M, Baltzer PAT (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 92
Pages Range: 51-57
DOI: 10.1016/j.ejrad.2017.04.014
Abstract
OBJECTIVES: To investigate whether the evaluation of multiple spectral regions can increase the diagnostic performance of 1H-MRS of the breast and reduce false positive findings. METHODS: 93 patients (mean age 56 years, range 23-79) undergoing breast MRI for routine clinical indications on a 1.5T scanner were eligible for this IRB-approved prospective study. Suspicious enhancing lesions ≥8mm underwent single-voxel point-resolved 1H-MRS (PRESS, TR=2000ms, TE=272ms). Histology showed 69 malignant and 24 benign lesions. The Signal-to-Noise ratio of choline, olefinic acids and the water-to-methylene ratio were measured. The area under the ROC-curve (AUC) was used to evaluate single measurements. Combined diagnostic accuracy was explored using a 10-fold cross-validated Chi-squared automatic interaction detection (CHAID) analysis. Inter-reader agreement was evaluated in a subset of patients. RESULTS: A significant AUC for differentiation between benign and malignant lesions was identified for choline (0.733, P=0.001), olefinic acids (0.769, P=0.0001) and water-to-methylene ratio (0.704, P=0.003). All three variables were included in a classification algorithm using CHAID methodology. Using this classification, 70.8% (17/24) false positive diagnoses in benign lesions would have been avoided. Inter-reader agreement was almost perfect. CONCLUSIONS: The combined evaluation of multiple spectral regions can increase the diagnostic performance of 1H-MRS and potentially reduce false positive findings.
Authors with CRIS profile
Involved external institutions
Austria (AT)
Switzerland (CH)How to cite
APA:
Clauser, P., Marcon, M., Dietzel, M., & Baltzer, P.A.T. (2017). A new method to reduce false positive results in breast MRI by evaluation of multiple spectral regions in proton MR-spectroscopy. European Journal of Radiology, 92, 51-57. https://doi.org/10.1016/j.ejrad.2017.04.014
MLA:
Clauser, Paola, et al. "A new method to reduce false positive results in breast MRI by evaluation of multiple spectral regions in proton MR-spectroscopy." European Journal of Radiology 92 (2017): 51-57.
BibTeX: Download