Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment

Journal article


Publication Details

Author(s): Oeckl P, Halbgebauer S, Anderl-Straub S, Steinacker P, Huss AM, Neugebauer H, Von Arnim CAF, Diehl-Schmid J, Grimmer T, Kornhuber J, Lewczuk P, Danek A, Ludolph AC, Otto M
Journal: Journal of Alzheimers Disease
Publication year: 2019
Volume: 67
Journal issue: 2
Pages range: 481-488
ISSN: 1387-2877


Abstract

Reliable blood biomarkers for Alzheimer's disease (AD) are missing. We measured astroglial GFAP in patients with AD (n = 28), frontotemporal dementia (bvFTD, n = 35), Parkinson's disease (n = 11), Lewy body dementias (n = 19), and controls (n = 34). Serum GFAP was increased in AD (p < 0.001) and DLB/PDD (p < 0.01), and cerebrospinal fluid GFAP was increased in all neurodegenerative diseases (p < 0.001). Serum GFAP correlated with the Mini-Mental State Examination score (r = -0.42, p < 0.001) and might be a follow-up marker in clinical trials. Sensitivity and specificity of serum GFAP for AD versus bvFTD was 89% and 79% and might be the first blood biomarker in the differential diagnosis of AD and bvFTD.


FAU Authors / FAU Editors

Kornhuber, Johannes Prof. Dr. med.
Lehrstuhl für Psychiatrie und Psychotherapie
Lewczuk, Piotr Prof. Dr.
Psychiatrische und Psychotherapeutische Klinik


External institutions
Ludwig-Maximilians-Universität (LMU)
Technische Universität München (TUM)
Universitätsklinikum Ulm


How to cite

APA:
Oeckl, P., Halbgebauer, S., Anderl-Straub, S., Steinacker, P., Huss, A.M., Neugebauer, H.,... Otto, M. (2019). Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment. Journal of Alzheimers Disease, 67(2), 481-488. https://dx.doi.org/10.3233/JAD-180325

MLA:
Oeckl, Patrick, et al. "Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment." Journal of Alzheimers Disease 67.2 (2019): 481-488.

BibTeX: 

Last updated on 2019-25-02 at 08:38