Tapering biologic and conventional DMARD therapy in rheumatoid arthritis: current evidence and future directions
Schett G, Emery P, Tanaka Y, Burmester G, Pisetsky DS, Naredo E, Fautrel B, Van Vollenhoven R (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 75
Pages Range: 1428-37
Journal Issue: 8
DOI: 10.1136/annrheumdis-2016-209201
Abstract
Improvements in the control of inflammation in rheumatoid arthritis (RA) by conventional synthetic and biologic disease-modifying antirheumatic drugs (DMARDs) have led to a substantial change in the clinical outcomes of patients during the last 30 years. Current treatment can lead to sustained remission in some patients raising questions about the optimal management strategies in this subgroup of patients. Today, tapering of DMARDs and even their discontinuation appears as an interesting concept for achieving a more tailored and dynamic treatment approach of RA, especially in patients, who achieved full disease control by DMARD treatment. In this review article, current developments of DMARD tapering are discussed. The article provides an overview of existing studies on this topic and addresses new strategies to reach drug-free remission. Furthermore, concepts for defining patients eligible for DMARD tapering are described and potential future strategies in using biomarkers in predicting the risk for disease relapse after initiation of DMARD tapering are addressed. These findings are finally considered in light of the vision to achieve cure as an ultimate goal in patients with RA achieving full control of inflammation.
Authors with CRIS profile
Involved external institutions
Amsterdam Rheumatology & immunology Center (ARC)
Netherlands (NL)
Pitié-Salpêtrière University Hospital / Hôpital universitaire Pitié-Salpêtrière
France (FR)
Hospital General Universitario Gregorio Marañón
Spain (ES)
Duke University
United States (USA) (US)
University of Occupational and Environmental Health Japan / 産業医科大学
Japan (JP)
Charité - Universitätsmedizin Berlin
Germany (DE)
Chapel Allerton Hospital
United Kingdom (GB)
Netherlands (NL)
Pitié-Salpêtrière University Hospital / Hôpital universitaire Pitié-Salpêtrière
France (FR)
Hospital General Universitario Gregorio Marañón
Spain (ES)
Duke University
United States (USA) (US)
University of Occupational and Environmental Health Japan / 産業医科大学
Japan (JP)
Charité - Universitätsmedizin Berlin
Germany (DE)
Chapel Allerton Hospital
United Kingdom (GB)
How to cite
APA:
Schett, G., Emery, P., Tanaka, Y., Burmester, G., Pisetsky, D.S., Naredo, E.,... Van Vollenhoven, R. (2016). Tapering biologic and conventional DMARD therapy in rheumatoid arthritis: current evidence and future directions. Annals of the Rheumatic Diseases, 75(8), 1428-37. https://doi.org/10.1136/annrheumdis-2016-209201
MLA:
Schett, Georg, et al. "Tapering biologic and conventional DMARD therapy in rheumatoid arthritis: current evidence and future directions." Annals of the Rheumatic Diseases 75.8 (2016): 1428-37.
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