Signature of circulating microRNAs in osteoarthritis

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Beyer C, Zampetaki A, Lin NY, Kleyer A, Perricone C, Iagnocco A, Distler A, Langley SR, Gelse K, Sesselmann S, Lorenzini R, Niemeier A, Swoboda B, Distler J, Santer P, Egger G, Willeit J, Mayr M, Schett G, Kiechl S
Zeitschrift: Annals of the Rheumatic Diseases
Jahr der Veröffentlichung: 2015
Band: 74
Heftnummer: 3
Seitenbereich: e18
ISSN: 0003-4967


Abstract


Osteoarthritis is the most common form of arthritis and a major socioeconomic burden. Our study is the first to explore the association between serum microRNA levels and the development of severe osteoarthritis of the knee and hip joint in the general population.We followed 816 Caucasian individuals from 1995 to 2010 and assessed joint arthroplasty as a definitive outcome of severe osteoarthritis of the knee and hip. After a microarray screen, we validated 12 microRNAs by real-time PCR in the entire cohort at baseline.In Cox regression analysis, three microRNAs were associated with severe knee and hip osteoarthritis. let-7e was a negative predictor for total joint arthroplasty with an adjusted HR of 0.75 (95% CI 0.58 to 0.96; p=0.021) when normalised to U6, and 0.76 (95% CI 0.6 to 0.97; p=0.026) after normalisation to the Ct average. miRNA-454 was inversely correlated with severe knee or hip osteoarthritis with an adjusted HR of 0.77 (95% CI 0.61 to 0.97; p=0.028) when normalised to U6. This correlation was lost when data were normalised to Ct average (p=0.118). Finally, miRNA-885-5p showed a trend towards a positive relationship with arthroplasty when normalised to U6 (HR 1.24; 95% CI 0.95 to 1.62; p=0.107) or to Ct average (HR 1.30; 95% CI 0.99 to 1.70; p=0.056).Our study is the first to identify differentially expressed circulating microRNAs in osteoarthritis patients necessitating arthroplasty in a large, population-based cohort. Among these microRNAs, let-7e emerged as potential predictor for severe knee or hip osteoarthritis.



FAU-Autoren / FAU-Herausgeber

Beyer, Christian PD Dr.
Medizinische Klinik 3 - Rheumatologie und Immunologie
Distler, Jörg PD Dr.
Heisenberg-Professur für Molekulare Mechanismen der Organfibrose
Kleyer, Arnd Dr. med.
Medizinische Klinik 3 - Rheumatologie und Immunologie
Schett, Georg Prof. Dr. med.
Lehrstuhl für Innere Medizin III
Sesselmann, Stefan Dr.
Lehrstuhl für Orthopädie mit Orthopädischer Chirurgie
Swoboda, Bernd Prof. Dr.
Professur für Orthopädische Rheumatologie


Autor(en) der externen Einrichtung(en)
King’s College London
Krankenhaus Bruneck / Ospedale di Brunico
Medizinische Universität Innsbruck
Università degli studi "La Sapienza"
Universitätsklinikum Hamburg-Eppendorf (UKE)


Zitierweisen

APA:
Beyer, C., Zampetaki, A., Lin, N.-Y., Kleyer, A., Perricone, C., Iagnocco, A.,... Kiechl, S. (2015). Signature of circulating microRNAs in osteoarthritis. Annals of the Rheumatic Diseases, 74(3), e18. https://dx.doi.org/10.1136/annrheumdis-2013-204698

MLA:
Beyer, Christian, et al. "Signature of circulating microRNAs in osteoarthritis." Annals of the Rheumatic Diseases 74.3 (2015): e18.

BibTeX: 

Zuletzt aktualisiert 2018-10-10 um 02:17