IKK? Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Goektuna SI, Canli O, Bollrath J, Fingerle AA, Horst D, Diamanti MA, Pallangyo C, Bennecke M, Nebelsiek T, Mankan AK, Lang R, Artis D, Hu Y, Patzelt T, Ruland J, Kirchner T, Taketo MM, Chariot A, Arkan MC, Greten FR
Zeitschrift: Cell Reports
Jahr der Veröffentlichung: 2014
Band: 7
Heftnummer: 6
Seitenbereich: 1914-25
ISSN: 2211-1247


Abstract


The recruitment of immune cells into solid tumors is an essential prerequisite of tumor development. Depending on the prevailing polarization profile of these infiltrating leucocytes, tumorigenesis is either promoted or blocked. Here, we identify I?B kinase ? (IKK?) as a central regulator of a tumoricidal microenvironment during intestinal carcinogenesis. Mice deficient in IKK? kinase activity are largely protected from intestinal tumor development that is dependent on the enhanced recruitment of interferon ? (IFN?)-expressing M1-like myeloid cells. In IKK? mutant mice, M1-like polarization is not controlled in a cell-autonomous manner but, rather, depends on the interplay of both IKK? mutant tumor epithelia and immune cells. Because therapies aiming at the tumor microenvironment rather than directly at the mutated cancer cell may circumvent resistance development, we suggest IKK? as a promising target for colorectal cancer (CRC) therapy.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Lang, Roland Prof. Dr.
Professur für Angeborene Immunität und Pathogenerkennung


Einrichtungen weiterer Autorinnen und Autoren

Kyoto University / 京都大学 Kyōto daigaku
Ludwig-Maximilians-Universität (LMU)
National Cancer Institute (NCI)
Technische Universität München (TUM)
University of Liège (ULg) / Université de Liège
University of Pennsylvania


Zitierweisen

APA:
Goektuna, S.I., Canli, O., Bollrath, J., Fingerle, A.A., Horst, D., Diamanti, M.A.,... Greten, F.R. (2014). IKK? Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells. Cell Reports, 7(6), 1914-25. https://dx.doi.org/10.1016/j.celrep.2014.05.006

MLA:
Goektuna, Serkan I., et al. "IKK? Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells." Cell Reports 7.6 (2014): 1914-25.

BibTeX: 

Zuletzt aktualisiert 2019-11-04 um 13:32