FcγRs in health and disease.
Nimmerjahn F, Ravetch JV (2011)
Publication Status: Published
Publication Type: Journal article, Review article
Publication year: 2011
Journal
Book Volume: 350
Pages Range: 105-25
DOI: 10.1007/82_2010_86
Abstract
Genetic defects affecting the humoral immune response and especially the production of antibodies of the immunoglobulin G (IgG) isotype result in a heightened susceptibility to infections. Studies over the last years have demonstrated the crucial role of Fc-receptors for IgG (FcγRs) widely expressed on innate immune effector cells in mediating the protective function of IgG. During the last years, additional ligands interacting with FcγRs as well as additional receptors binding to IgG glycosylation variants have been identified. In this review, we discuss how the interaction of these different ligands with classical and novel Fcγ-receptors influences the immune response and which strategies microorganisms have developed to prevent them.
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United States (USA) (US)How to cite
APA:
Nimmerjahn, F., & Ravetch, J.V. (2011). FcγRs in health and disease. Current Topics in Microbiology and Immunology, 350, 105-25. https://doi.org/10.1007/82_2010_86
MLA:
Nimmerjahn, Falk, and J. V. Ravetch. "FcγRs in health and disease." Current Topics in Microbiology and Immunology 350 (2011): 105-25.
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