In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Atreya R, Neumann H, Neufert C, Waldner M, Billmeier U, Zopf Y, Willma M, App C, Münster T, Kessler H, Maas S, Gebhardt B, Heimke-Brinck R, Reuter E, Dörje F, Rau T, Uter W, Wang TD, Kiesslich R, Vieth M, Hannappel E, Neurath M
Zeitschrift: Nature Medicine
Verlag: Nature Publishing Group
Jahr der Veröffentlichung: 2014
Band: 20
Heftnummer: 3
Seitenbereich: 313-8
ISSN: 1078-8956


Abstract


As antibodies to tumor necrosis factor (TNF) suppress immune responses in Crohn's disease by binding to membrane-bound TNF (mTNF), we created a fluorescent antibody for molecular mTNF imaging in this disease. Topical antibody administration in 25 patients with Crohn's disease led to detection of intestinal mTNF(+) immune cells during confocal laser endomicroscopy. Patients with high numbers of mTNF(+) cells showed significantly higher short-term response rates (92%) at week 12 upon subsequent anti-TNF therapy as compared to patients with low amounts of mTNF(+) cells (15%). This clinical response in the former patients was sustained over a follow-up period of 1 year and was associated with mucosal healing observed in follow-up endoscopy. These data indicate that molecular imaging with fluorescent antibodies has the potential to predict therapeutic responses to biological treatment and can be used for personalized medicine in Crohn's disease and autoimmune or inflammatory disorders.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

App, Christine
Lehrstuhl für Biochemie und Pathobiochemie
Atreya, Raja Prof. Dr.
Juniorprofessur für chronisch entzündliche Darmerkrankungen
Dörje, Frank Prof. Dr.
Lehrstuhl für Pharmazeutische Technologie
Hannappel, Ewald Prof. Dr.
Professur für Biochemie
Münster, Tino Prof. Dr.
Anästhesiologische Klinik
Neufert, Clemens PD Dr.
Medizinische Fakultät
Neurath, Markus Prof. Dr.
Lehrstuhl für Innere Medizin I
Uter, Wolfgang Prof. Dr.
Professur für Epidemiologie
Waldner, Maximilian Prof. Dr.
Professur für Funktionelle Bildgebung in der Medizin
Zopf, Yurdagül PD Dr.
Medizinische Klinik 1 - Gastroenterologie, Pneumologie und Endokrinologie


Einrichtungen weiterer Autorinnen und Autoren

Klinikum Bayreuth
Saint Mary's Hospital
University of Michigan


Zitierweisen

APA:
Atreya, R., Neumann, H., Neufert, C., Waldner, M., Billmeier, U., Zopf, Y.,... Neurath, M. (2014). In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease. Nature Medicine, 20(3), 313-8. https://dx.doi.org/10.1038/nm.3462

MLA:
Atreya, Raja, et al. "In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease." Nature Medicine 20.3 (2014): 313-8.

BibTeX: 

Zuletzt aktualisiert 2018-09-10 um 02:20