Optimization of the mechanical properties of calcium phosphate/multi-walled carbon nanotubes/bovine serum albumin composites using response surface methodology

Low KL, Tan SH, Zein SHS, Mcphail DS, Boccaccini AR (2011)

Publication Type: Journal article

Publication year: 2011

Journal

Materials & Design Elsevier

Publisher: Elsevier BV

Pages Range: 3312-3319

Journal Issue: 32

DOI: 10.1016/j.matdes.2011.02.022

Abstract

Response surface methodology (RSM) coupled with the central composite design (CCD) was used to optimize the mechanical properties of calcium phosphate cement/multi-walled carbon nanotubes/bovine serum albumin (CPC/MWCNTs/BSA) composites. In this study, CPC composites were reinforced by multi-walled carbon nanotubes (MWCNTs) and bovine serum albumin (BSA) in order to induce high mechanical properties in the CPC/MWCNTs/BSA system. The effect of various process parameters on the compressive strength of CPC/MWCNTs/BSA composites was studied using design of experiments (DOE). The process parameters studied were: wt.% of MWCNTs (0.2-0.5 wt.%), wt.% of BSA (5-15. wt.%) and type of MWCNTs (e.g. as-pristine MWCNT (MWCNT-AP), hydroxyl group functionalized MWCNT (MWCNT-OH) and carboxyl group functionalized MWCNT (MWCNT-COOH)). Based on the CCD, a quadratic model was obtained to correlate the process parameters to the compressive strength of CPC/MWCNTs/BSA composites. From the analysis of variance (ANOVA), the most significant factor affected on the experimental design response was identified. The predicted compressive strength after process optimization was found to agree well with the experimental value. The results revealed that at 0.5. wt.% of MWCNT-OH and 15. wt.% of BSA, the highest compressive strength of 14. MPa was obtained. © 2011 Elsevier Ltd.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

University of Science Malaysia (USM) / Universiti Sains Malaysia MY Malaysia (MY) Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB)

How to cite

APA:

Low, K.L., Tan, S.H., Zein, S.H.S., Mcphail, D.S., & Boccaccini, A.R. (2011). Optimization of the mechanical properties of calcium phosphate/multi-walled carbon nanotubes/bovine serum albumin composites using response surface methodology. Materials & Design, 32, 3312-3319. https://doi.org/10.1016/j.matdes.2011.02.022

MLA:

Low, Kah Ling, et al. "Optimization of the mechanical properties of calcium phosphate/multi-walled carbon nanotubes/bovine serum albumin composites using response surface methodology." Materials & Design 32 (2011): 3312-3319.

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