ELM--the database of eukaryotic linear motifs

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Dinkel H, Michael S, Weatheritt RJ, Davey NE, Van Roey K, Altenberg B, Toedt G, Uyar B, Seiler M, Budd A, Joedicke L, Dammert MA, Schroeter C, Hammer M, Schmidt T, Jehl P, Mcguigan C, Dymecka M, Chica C, Luck K, Via A, Chatr-Aryamontri A, Haslam N, Grebnev G, Edwards RJ, Steinmetz MO, Meiselbach H, Diella F, Gibson TJ
Zeitschrift: Nucleic Acids Research
Verlag: Oxford University Press (OUP): Policy C - Option B / Oxford University Press
Jahr der Veröffentlichung: 2012
Band: 40
Heftnummer: D1
Seitenbereich: D242-D251
ISSN: 0305-1048
eISSN: 1362-4962


Abstract

Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspect of the regulatory functionality of the cell. They are particularly prominent in mediating cell signaling, controlling protein turnover and directing protein localization. Given their importance, our understanding of motifs is surprisingly limited, largely as a result of the difficulty of discovery, both experimentally and computationally. The Eukaryotic Linear Motif (ELM) resource at http://elm.eu.org provides the biological community with a comprehensive database of known experimentally validated motifs, and an exploratory tool to discover putative linear motifs in user-submitted protein sequences. The current update of the ELM database comprises 1800 annotated motif instances representing 170 distinct functional classes, including approximately 500 novel instances and 24 novel classes. Several older motif class entries have been also revisited, improving annotation and adding novel instances. Furthermore, addition of full-text search capabilities, an enhanced interface and simplified batch download has improved the overall accessibility of the ELM data. The motif discovery portion of the ELM resource has added conservation, and structural attributes have been incorporated to aid users to discriminate biologically relevant motifs from stochastically occurring non-functional instances.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Meiselbach, Heike
Sonderforschungsbereich 796 (mit integriertem Graduiertenkolleg) Steuerungsmechanismen mikrobieller Effektoren in Wirtszellen


Einrichtungen weiterer Autorinnen und Autoren

European Molecular Biology Laboratory (EMBL)
French Alternative Energies and Atomic Energy Commission (CEA)
Maria Skłodowska-Curie Institute of Oncology / Centrum Onkologii–Instytut im. Marii Skłodowskiej-Curie w Warszawie
Paul Scherrer Institute (PSI)
Università degli studi "La Sapienza"
Université de Strasbourg (UDS)
University College Dublin (UCD)
University of Edinburgh
University of Southampton


Zitierweisen

APA:
Dinkel, H., Michael, S., Weatheritt, R.J., Davey, N.E., Van Roey, K., Altenberg, B.,... Gibson, T.J. (2012). ELM--the database of eukaryotic linear motifs. Nucleic Acids Research, 40(D1), D242-D251. https://dx.doi.org/10.1093/nar/gkr1064

MLA:
Dinkel, Holger, et al. "ELM--the database of eukaryotic linear motifs." Nucleic Acids Research 40.D1 (2012): D242-D251.

BibTeX: 

Zuletzt aktualisiert 2018-05-10 um 02:29