Etablierung eines Herzunterstützungssystems basierend auf einer dem Herzbeutel nachgebildeten kontraktilen Membran
(Establishment of a heart support system as a contractile membrane based on the pericardium)

Third party funded individual grant


Project Details

Project leader:
Prof. Dr.-Ing. Sigrid Leyendecker

Project members:
Dr.-Ing. Minh Tuan Duong
David Holz
Denisa Martonova

Contributing FAU Organisations:
Chair of Applied Dynamics
Franz-Penzoldt-Zentrum
Kinderkardiologische Abteilung in der Kinder- und Jugendklinik
Radiologisches Institut

Funding source: Stiftungen (Klaus Tschira Stiftung)
Start date: 01/05/2016
End date: 31/03/2021


Research Fields

biomechanics
Chair of Applied Dynamics


Abstract (technical / expert description):

This project
contains the establishment of a heart support system as a contractile membrane based on the pericardium to minimize the
consequences of severe heart disease and to maintain proper cardiac
function. The project is a research cooperation between the Chair of
Applied Dynamics and the Pediatric Cardiology at the University of Erlangen
Nuremberg and is funded by the Klaus Tschira Foundation.



The project includes the study of
cardiac function under pathological and normal conditions by developing
computer models of the heart, which are validated with experimental data of
pediatric cardiology of the University of Erlangen Nuremberg. The clinical
measurements and experimental data, as well as the simulation model are based
on rat hearts. Subsequently, a cardiac support system based on a membrane is to
be designed to improve or at least maintain heart function under pathological
conditions.



In particular at
the Chair of Applied Dynamics, we are focusing on the development of the
underlying computational heart model including the anatomy, morphology,
electrophysiology and also the fluid-structure interaction to be able to build
up the optimized heart support system but also to better understand the
function of the heart and thus to predict or early detect cardiac dysfunctions and
bring new treatments to the clinic. 


Publications

Holz, D., Duong, M.T., Alkassar, M., Dittrich, S., & Leyendecker, S. (2019). Computational study of ventricular fibrillation by considering a strongly coupled electromechanical rat heart model. In Proceedings of the GAMM Annual Meeting. Wien, AT.
Duong, M.T., Holz, D., Alkassar, M., Dittrich, S., & Leyendecker, S. (2019). Interaction of the mechano-electrical feedback with passive mechanical models on a 3D rat left ventricle: a computational study. Frontiers in Physiology, 10, 10-41. https://dx.doi.org/10.3389/fphys.2019.01041
Holz, D., Duong, M.T., Martonova, D., Alkassar, M., Dittrich, S., & Leyendecker, S. (2019). Möglichkeiten und Perspektiven der Modellierung und Simulation. In Tagungsband Wissenschaftliche Jahrestagung der Deutschen Gesellschaft für Thorax-, Herz- und Gefäßchirurgie. Wiesbaden, DE.
Holz, D., Duong, M.T., Kim, M., Alkassar, M., Dittrich, S., & Leyendecker, S. (2019). Nonlinear fibre distribution in a finite element model of a human left ventricle for sparse and non-constant data sets. In Proceedings of the 8th GACM Colloquium on Computational Mechanics. Kassel, DE.
Holz, D., Duong, M.T., Kim, M., Alkassar, M., Dittrich, S., & Leyendecker, S. (2019). Nonlinear fibre distribution in cardiac modelling. In Proceedings of the 25th Congress of the European Society of Biomechanics. Wien, AT.
Holz, D., Duong, M.T., Alkassar, M., Dittrich, S., & Leyendecker, S. (2018). Computational model of a rat left ventricle. In Workshop. Graz.
Duong, M.T., Holz, D., Ach, T., Binnewitt, S.V., Stegmann, H., Dittrich, S.,... Leyendecker, S. (2018). Simulation of cardiac electromechanics of a rat left ventricle. In Proceedings of the GAMM Annual Meeting. München, DE.
Holz, D. (2017). Computing fibre orientation for a finite element model of a rat heart (Master thesis).
Duong, M.T., Wenger, T., Herrnböck, L., Ach, T., Holz, D., Kreipp, A.,... Leyendecker, S. (2017). Modelling cardiac mechanics and electrophysiology of a rat left ventricle: A case study. In Proceedings of the International Conference on Biomedical Technology. Hannover, DE.

Last updated on 2019-26-08 at 17:40