Etablierung eines Herzunterstützungssystems basierend auf einer dem Herzbeutel nachgebildeten kontraktilen Membran
(Establishment of a heart support system as a contractile membrane based on the pericardium)

Drittmittelfinanzierte Einzelförderung

Details zum Projekt

Prof. Dr.-Ing. Sigrid Leyendecker

Dr.-Ing. Minh Tuan Duong
David Holz

Beteiligte FAU-Organisationseinheiten:
Kinderkardiologische Abteilung in der Kinder- und Jugendklinik
Lehrstuhl für Technische Dynamik
Radiologisches Institut

Mittelgeber: Stiftungen (Klaus Tschira Stiftung)
Projektstart: 01.05.2016
Projektende: 31.12.2018


Lehrstuhl für Technische Dynamik

Abstract (fachliche Beschreibung):

This project contains the establishment of a heart support system as a contractile membrane based on the pericardium to minimize the consequences of severe heart disease and to maintain proper cardiac function. The project is a research cooperation between the Chair of Applied Dynamics and the Pediatric Cardiology at the University of Erlangen Nuremberg and is funded by the Klaus Tschira Foundation.

The project includes the study of cardiac function under pathological and normal conditions by developing computer models of the heart, which are validated with experimental data of pediatric cardiology of the University of Erlangen Nuremberg. The clinical measurements and experimental data, as well as the simulation model are based on rat hearts. Subsequently, a cardiac support system based on a membrane is to be designed to improve or at least maintain heart function under pathological conditions.

In particular at the Chair of Applied Dynamics, we are focusing on the development of the underlying computational heart model including the anatomy, morphology, electrophysiology and also the fluid-structure interaction to be able to build up the optimized heart support system but also to better understand the function of the heart and thus to predict or early detect cardiac dysfunctions and bring new treatments to the clinic. 


Duong, M.T., Holz, D., Ach, T., Binnewitt, S.V., Stegmann, H., Dittrich, S.,... Leyendecker, S. (2018). Simulation of cardiac electromechanics of a rat left ventricle. München, DE.
Duong, M.T., Wenger, T., Herrnböck, L., Ach, T., Holz, D., Kreipp, A.,... Leyendecker, S. (2017). Modelling cardiac mechanics and electrophysiology of a rat left ventricle: A case study. Hannover, DE.

Zuletzt aktualisiert 2018-27-07 um 12:49