Cooperative Action of SNARE Peptides in Fusion

Third Party Funds Group - Sub project

Overall project details

Overall project: SFB1027: Physical modeling of non-equilibrium processes in biological systems (Saarland University)

Project Details

Project leader:
Prof. Dr. Rainer Böckmann

Contributing FAU Organisations:
Professur für Computational Biology

Funding source: Deutsche Forschungsgemeinschaft (DFG)
Acronym: SFB1027
Start date: 01/01/2017
End date: 31/12/2020

Abstract (technical / expert description):

SNARE peptides act cooperatively during synaptic vesicle fusion. It has previously been suggested that oligomerization of SNARE complexes, which is required for cooperative action in fusion is mediated by interactions between their transmembrane domains (TMDs) and further tuned by interactions with the lipid environment. In this project, the oligomerization of SNARE TMD peptides, their interaction with the lipid surrounding, and the peptide-induced membrane curvature and its influence on membrane fusion will be studied using molecular dynamics simu- lations. 

Last updated on 2018-22-11 at 18:01