Dr. Jennifer Munkert



Organisationseinheit


Lehrstuhl für Pharmazeutische Biologie


Preise / Auszeichnungen

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2015 : BAYLAT-Anschubfinanzierung für neue Projekte mit Lateinamerika
2015 : FAU Universitätsbund Erlangen-Nürnberg e.V. - Anschubfinanzierung
2014 : FFL Stipendium der FAU
2014 : Forschungspreis 2014 der Gustav-Adolf und Erika Dornhecker Stiftung
2013 : Reisestipendium (short-term scientific mission) der European Cooperation in Science and Technology (COST)


Mitarbeit in Forschungsprojekten


(The genus Digitalis: Molecular taxonomy, preservation, active constituents and therapeutic applications):
DIGITALIS: The genus Digitalis: Molecular taxonomy, preservation, active constituents and therapeutic applications
Prof. Dr. Wolfgang Kreis
(01.05.2012 - 30.04.2016)


Weitere Forschungsaktivitäten

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Vortragstätigkeit
Dr. Jennifer Munkert
Biotransformation of Digitoxigenine-monodigitoxoside to Glucoevatromonoside in D. lanta K1OHD suspension cells
Vortragstätigkeit
Dr. Jennifer Munkert
Cardiac glycosides and their semisynthetic derivates - potential in tumor therapy?
Vortragstätigkeit
Dr. Jennifer Munkert
Establishment and evaluation of processes for the production of the antiviral and cytostatic cardiac glycoside glucoevatromonosid
Vortragstätigkeit
Dr. Jennifer Munkert
Iridoid synthase activity is common among the plant progesterone 5β-reductase family
Vortragstätigkeit
Dr. Jennifer Munkert
Evolution and function of putative enzymes of cardenolide synthesis


Publikationen (Download BibTeX)

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Schneider, N.F.Z., Cerella, C., Lee, J.-Y., Mazumder, A., Kim, K.R., de Carvalho, A.,... Diederich, M. (2018). Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-specific Cell Death. Frontiers in Pharmacology, 9. https://dx.doi.org/10.3389/fphar.2018.00070
Silva, I.T., Munkert, J., Nolte, E., Schneider, N.F.Z., Rocha, S.C., Ramos, A.C.P.,... Simões, C.M.O. (2018). Cytotoxicity of AMANTADIG - a semisynthetic digitoxigenin derivative - alone and in combination with docetaxel in human hormone-refractory prostate cancer cells and its effect on Na+/K+ -ATPase inhibition. Biomedicine & Pharmacotherapy, 107, 464-474. https://dx.doi.org/10.1016/j.biopha.2018.08.028
Gomes, E.R., Novais, M.V.M., Silva, I.T., Barros, A.L.B., Leite, E.A., Munkert, J.,... Oliveira, M.C. (2018). Long-circulating and fusogenic liposomes loaded with a glucoevatromomoside derivative induce potent antitumor response. Biomedicine & Pharmacotherapy, 108, 1152 - 1161. https://dx.doi.org/10.1016/j.biopha.2018.09.109
Schmidt, K., Petersen, J.-H., Munkert, J., Egerer-Sieber, C., Hornig, M., Muller, Y., & Kreis, W. (2018). PRISEs (progesterone 5β-reductase and/or iridoid synthase-like 1,4-enone reductases): Catalytic and substrate promiscuity allows for realization of multiple pathways in plant metabolism. Phytochemistry, 156, 9-19. https://dx.doi.org/10.1016/j.phytochem.2018.08.012
Nolte, E., Wach, S., Silva, I.T., Lukat, S., Ekici, A.B., Munkert, J.,... Lai, X. (2017). A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines. Oncotarget. https://dx.doi.org/10.18632/oncotarget.14644
Kreis, W., Munkert, J., & De Padua, R.M. (2017). Biossíntese de metabólitos primários e secundários. In Letícia Bispo de Lima (Eds.), Farmacognosia do Produto Natural ao Medicamento (pp. 147 - 166). Porto Alegre, Brazil: Artmed Editora Ltda..
Schneider, N.F.Z., Persich, L., Rocha, S.C., Ramos, A.C.P., Cortes, V.F., Silva, I.T.,... Simões, C.M.O. (2017). Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase. Biomedicine & Pharmacotherapy, 97, 684-696. https://dx.doi.org/10.1016/j.biopha.2017.10.128
Munkert, J., & Kreis, W. (2017). Herzglykoside und ihr Potenzial für die Tumortherapie. Deutsche Zeitschrift für Onkologie, 49(3), 129-135. https://dx.doi.org/10.1055/s-0043-115681
Munkert, J., Santiago Franco, M., Nolte, E., Silva, I.T., Oliveira Castilho, R., Ottoni, F.M.,... De Padua, R.M. (2017). Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture. Planta medica. https://dx.doi.org/10.1055/s-0043-109557
Meitinger, N., Munkert, J., Maia de Pádua, R., De Souza Filho, J.D., Maid, H., Bauer, W.,... Kreis, W. (2016). The catalytic mechanism of the 3-ketosteroid isomerase of Digitalis lanata involves an intramolecular proton transfer and the activity is not associated with the 3 beta-hydroxysteroid dehydrogenase activity. Tetrahedron Letters, 57(14), 1567-1571. https://dx.doi.org/10.1016/j.tetlet.2016.02.099

Zuletzt aktualisiert 2016-05-05 um 05:05