Biomimetic molecular recognition of nucleotides by macrocyclic and cage hosts in water
He T, Akhgaramirabadi M, Cao L, Kataev E (2026)
Publication Type: Journal article, Review article
Publication year: 2026
Journal
DOI: 10.1039/d5cs01260k
Abstract
Nucleotides are essential molecules in biology, acting as building blocks of DNA and RNA, energy carriers, and signalling molecules. They also function as coenzymes that support key metabolic and catalytic processes. This tutorial focuses on the development of synthetic receptors—especially macrocyclic and cage-like structures—that can selectively bind nucleotides. Studying these systems helps scientists better understand molecular recognition in biology and enables techniques like monitoring nucleotide levels in cells. The review emphasizes recent progress in receptor design, exploring their structures, binding mechanisms, and factors affecting selectivity, such as shape, conformation, and chemical interactions. It also covers experimental techniques and applications, highlighting how understanding noncovalent interactions can inform the development of new functional materials, catalysts, and drugs.
Authors with CRIS profile
Maryam Akhgaramirabadi
Lehrstuhl für Organische Chemie I
Evgeny Kataev
Department Chemie und Pharmazie
Involved external institutions
China (CN)How to cite
APA:
He, T., Akhgaramirabadi, M., Cao, L., & Kataev, E. (2026). Biomimetic molecular recognition of nucleotides by macrocyclic and cage hosts in water. Chemical Society Reviews. https://doi.org/10.1039/d5cs01260k
MLA:
He, Tianci, et al. "Biomimetic molecular recognition of nucleotides by macrocyclic and cage hosts in water." Chemical Society Reviews (2026).
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