Eichhorn M, Dmitrieva A, Meder L (2026)
Publication Type: Journal article, Review article
Publication year: 2026
Book Volume: 34
Journal Issue: 5
Squamous cell carcinoma (SCC) comprises a heterogeneous group of malignancies with distinct molecular characteristics, clinical behavior and therapeutic responses, highlighting the need for personalized treatment strategies. Circadian rhythms regulate fundamental physiological processes, including cell proliferation, metabolism, DNA repair and immune function, and emerging evidence suggests that circadian regulation may influence pathways relevant to SCC biology and treatment response. This review summarizes current knowledge on the role of circadian regulation in SCC, with particular emphasis on lung SCC, focusing on core clock genes, their interactions with oncogenic and immune‑related pathways, and their therapeutic implications. We discuss current evidence supporting chronotherapy as a potential component of personalized SCC treatment while addressing important limitations, including the predominance of preclinical studies, limited SCC‑specific clinical evidence and extrapolation from other tumor types. Finally, we outline key research priorities for translating circadian biology into clinical SCC management.
APA:
Eichhorn, M., Dmitrieva, A., & Meder, L. (2026). Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review). , 34(5). https://doi.org/10.3892/mmr.2026.14011
MLA:
Eichhorn, Michael, Anna Dmitrieva, and Lydia Meder. "Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review)." 34.5 (2026).
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