Dysphagia and gastrointestinal disorders in Parkinson’s disease: towards a diagnostic standard operating procedure for the interprofessional neurological outpatient care team

Claus I, Buhmann C, Fanciulli A, Klebe S, Marxreiter F, Süß P, Weise D, Warnecke T (2026)

Publication Type: Journal article, Review article

Publication year: 2026

Journal

Journal of Neural Transmission Springer Nature

DOI: 10.1007/s00702-026-03195-z

Abstract

Gastrointestinal Disorders in people with Parkinson’s disease (PwP) are able to cause widespread clinical symptoms which can be challenging to classify in day-to-day clinical practice. In the upper gastrointestinal tract (GIT) oropharyngeal dysphagia, esophageal motility disorders as well as delayed gastric emptying may cause nutrition problems and reduce the efficacy of oral pharmacotherapy. In the lower GIT, bacterial overgrowth and prolonged colorectal transit times induce different stages of constipation leading to reduced quality of life and GIT comorbidities as well. Most of these symptoms reflect alpha-synuclein pathology in both the enteric nervous system and at various sites of the peripheral and central nervous systems. Besides, the growing use of various device aided therapies may additionally raise specific clinical questions about the interference with the GIT motility. This standard operating procedure (SOP) is intended to provide specific recommendations for diagnostic steps as well as therapeutic options, especially for interprofessional neurological outpatient care teams.

Authors with CRIS profile

Patrick Süß Department of Molecular Neurology

Involved external institutions

Asklepios Fachklinikum Stadtroda / Asklepios Specialist Clinic Stadtroda DE Germany (DE) Universitätsklinikum Münster DE Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) Medizinische Universität Innsbruck AT Austria (AT) Behandlungszentrum Knappschaftskrankenhaus Recklinghausen DE Germany (DE) Klinikum Osnabrück DE Germany (DE)

How to cite

APA:

Claus, I., Buhmann, C., Fanciulli, A., Klebe, S., Marxreiter, F., Süß, P.,... Warnecke, T. (2026). Dysphagia and gastrointestinal disorders in Parkinson’s disease: towards a diagnostic standard operating procedure for the interprofessional neurological outpatient care team. Journal of Neural Transmission. https://doi.org/10.1007/s00702-026-03195-z

MLA:

Claus, Inga, et al. "Dysphagia and gastrointestinal disorders in Parkinson’s disease: towards a diagnostic standard operating procedure for the interprofessional neurological outpatient care team." Journal of Neural Transmission (2026).

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