Generation of 5 induced pluripotent stem cell lines with copy number variations in 22q11.2

Radtke F, Abbasov F, Chiocchetti A, Gücsavas D, Jung A, Kurth C, McNeill R, Nieberler M, Romanos M, Schickardt Z, Ziegler GC, Kittel-Schneider S (2026)

Publication Type: Journal article

Publication year: 2026

Journal

Stem Cell Research Elsevier

Book Volume: 95

Article Number: 104083

DOI: 10.1016/j.scr.2026.104083

Abstract

Copy number variations (deletions or duplications) in the 22q11.2 gene region are significantly correlated to a highly increased risk to develop mental disorder morbidity such as psychosis, attention-deficit/hyperactivity disorder (ADHD) or mood disorders. However, pathogenetic mechanisms are insufficiently understood. We generated iPSC from two deletion patients (one with major depressive disorder, one with specific phobia) and three duplication patients (one with recurrent major depressive disorder, one with ADHD, one with autistic traits). The iPSC lines represent a valuable resource to model pathogenesis in vitro.

Involved external institutions

Universitätsklinikum Würzburg DE Germany (DE) Universitätsklinikum Frankfurt am Main (KGU) DE Germany (DE)

How to cite

APA:

Radtke, F., Abbasov, F., Chiocchetti, A., Gücsavas, D., Jung, A., Kurth, C.,... Kittel-Schneider, S. (2026). Generation of 5 induced pluripotent stem cell lines with copy number variations in 22q11.2. Stem Cell Research, 95. https://doi.org/10.1016/j.scr.2026.104083

MLA:

Radtke, F., et al. "Generation of 5 induced pluripotent stem cell lines with copy number variations in 22q11.2." Stem Cell Research 95 (2026).

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