PSA and PSA kinetics thresholds for the presence of 68Ga-PSMA-11 PET/CT-detectable lesions in patients with biochemical recurrent prostate cancer

Hoffmann MA, Buchholz HG, Wieler HJ, Miederer M, Rosar F, Fischer N, Müller-Hübenthal J, Trampert L, Pektor S, Schreckenberger M (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Cancers MDPI

Book Volume: 12

Article Number: 398

Journal Issue: 2

DOI: 10.3390/cancers12020398

Abstract

68Ga-PSMA-11 positron-emission tomography/computed tomography (PET/CT) is commonly used for restaging recurrent prostate cancer (PC) in European clinical practice. The goal of this study is to determine the optimum time for performing these PET/CT scans in a large cohort of patients by identifying the prostate-specific-antigen (PSA) and PSA kinetics thresholds for detecting and localizing recurrent PC. This retrospective analysis includes 581 patients with biochemical recurrence (BC) by definition. The performance of 68Ga-PSMA-11 PET/CT in relation to the PSA value at the scan time as well as PSA kinetics was assessed by the receiver-operating-characteristic-curve (ROC) generated by plotting sensitivity versus 1-specificity. Malignant prostatic lesions were identified in 77%. For patients that were treated with radical prostatectomy (RP) a PSA value of 1.24 ng/mL was found to be the optimal cutoff level for predicting positive and negative scans, while for patients previously treated with radiotherapy (RT) it was 5.75 ng/mL. In RP-patients with PSA value <1.24 ng/mL, 52% scans were positive, whereas patients with PSA ≥1.24 ng/mL had positive scan results in 87%. RT-patients with PSA <5.75 ng/mL had positive scans in 86% and and for those with PSA ≥5.75 ng/mL 94% had positive scans. This study identifies the PSA and PSA kinetics threshold levels for the presence of 68Ga-PSMA-11 PET/CT-detectable PC-lesions in BC patients.

Involved external institutions

Johannes Gutenberg-Universität Mainz (JGU) DE Germany (DE) HELIOS Kliniken DE Germany (DE) Klinikum Mutterhaus der Borromäerinnen DE Germany (DE) Bundesministerium der Verteidigung / Bundeswehr DE Germany (DE) Bundeswehrzentralkrankenhaus Koblenz DE Germany (DE)

How to cite

APA:

Hoffmann, M.A., Buchholz, H.G., Wieler, H.J., Miederer, M., Rosar, F., Fischer, N.,... Schreckenberger, M. (2020). PSA and PSA kinetics thresholds for the presence of 68Ga-PSMA-11 PET/CT-detectable lesions in patients with biochemical recurrent prostate cancer. Cancers, 12(2). https://doi.org/10.3390/cancers12020398

MLA:

Hoffmann, Manuela Andrea, et al. "PSA and PSA kinetics thresholds for the presence of 68Ga-PSMA-11 PET/CT-detectable lesions in patients with biochemical recurrent prostate cancer." Cancers 12.2 (2020).

BibTeX: Download