Dual-time point [68ga]ga-psma-11 pet/ct hybrid imaging for staging and restaging of prostate cancer

Hoffmann MA, Buchholz HG, Wieler HJ, Rosar F, Miederer M, Fischer N, Schreckenberger M (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Cancers MDPI

Book Volume: 12

Pages Range: 1-15

Article Number: 2788

Journal Issue: 10

DOI: 10.3390/cancers12102788

Abstract

Routine [68Ga]Ga-PSMA-11 PET/CT (one hour post-injection) has been shown to accurately detect prostate cancer (PCa) lesions. The goal of this study is to evaluate the benefit of a dual-time point imaging modality for the staging and restaging of PCa patients. Biphasic [68Ga]Ga-PSMA-11 PET/CT of 233 patients, who underwent early and late scans (one/three hours post-injection), were retrospectively studied. Tumor uptake and biphasic lesion detection for 215 biochemically recurrent patients previously treated for localized PCa (prostatectomized patients (P-P)/irradiated patients (P-I) and 18 patients suspected of having primary PCa (P-T) were separately evaluated. Late [68Ga]Ga-PSMA-11 PET/CT imaging detected 554 PCa lesions in 114 P-P patients, 187 PCa lesions in 33 P-I patients, and 47 PCa lesions in 13 P-T patients. Most patients (106+32 P-P/P-I, 13 P-T) showed no additional PCa lesions. However, 11 PSMA-avid lesions were only detected in delayed images, and 33 lesions were confirmed as malignant by a SUVmax increase. The mean SUVmax of pelvic lymph node metastases was 25% higher (p < 0.001) comparing early and late PET/CT. High positivity rates from routine [68Ga]Ga-PSMA-11 PET/CT for the staging and restaging of PCa patients were demonstrated. There was no decisive influence of additional late imaging with PCa lesion detection on therapeutic decisions. However, in a few individual cases, additional delayed scans provided an information advantage in PCa lesion detection due to higher tracer uptake and improved contrast.

Involved external institutions

Johannes Gutenberg-Universität Mainz (JGU) DE Germany (DE) Bundeswehrzentralkrankenhaus Koblenz DE Germany (DE) Universität zu Köln DE Germany (DE) Bundesministerium der Verteidigung / Bundeswehr DE Germany (DE)

How to cite

APA:

Hoffmann, M.A., Buchholz, H.G., Wieler, H.J., Rosar, F., Miederer, M., Fischer, N., & Schreckenberger, M. (2020). Dual-time point [68ga]ga-psma-11 pet/ct hybrid imaging for staging and restaging of prostate cancer. Cancers, 12(10), 1-15. https://doi.org/10.3390/cancers12102788

MLA:

Hoffmann, Manuela A., et al. "Dual-time point [68ga]ga-psma-11 pet/ct hybrid imaging for staging and restaging of prostate cancer." Cancers 12.10 (2020): 1-15.

BibTeX: Download