Impact of prompt gamma emission of 44Sc on quantification in preclinical and clinical PET systems

Rosar F, Bohnenberger H, Moon ES, Rösch F, Denig A, Vincenz-Zörner D, Hoffmann MA, Khreish F, Ezziddin S, Schreckenberger M, Buchholz HG, Schaefer-Schuler A (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Applied Radiation and Isotopes Elsevier

Book Volume: 170

Article Number: 109599

DOI: 10.1016/j.apradiso.2021.109599

Abstract

44Sc is an increasingly investigated positron emitter for use in positron emission tomography (PET) imaging. However, 44Sc is a non-pure positron emitter, since prompt photons are co-emitted during the decay process. This study investigates coincidence energy spectra of 44Sc and its impact on PET quantification on a preclinical and clinical PET system in comparison with 18F. The raw data of the coincidence events revealed characteristic differences comparing the photon energy distribution of 44Sc and 18F. Due to prompt gamma emission of 44Sc, activity recovery is underestimated on PET systems. However, clinical PET imaging of 44Sc with acceptable quantitative accuracy appears feasible by using a single, constant correction factor.

Involved external institutions

Universitätsklinikum des Saarlandes (UKS) DE Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) DE Germany (DE) Mediso GmbH DE Germany (DE)

How to cite

APA:

Rosar, F., Bohnenberger, H., Moon, E.S., Rösch, F., Denig, A., Vincenz-Zörner, D.,... Schaefer-Schuler, A. (2021). Impact of prompt gamma emission of 44Sc on quantification in preclinical and clinical PET systems. Applied Radiation and Isotopes, 170. https://doi.org/10.1016/j.apradiso.2021.109599

MLA:

Rosar, Florian, et al. "Impact of prompt gamma emission of 44Sc on quantification in preclinical and clinical PET systems." Applied Radiation and Isotopes 170 (2021).

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