Comparison of [18F]PSMA-1007 with [68Ga]Ga-PSMA-11 PET/CT in Restaging of Prostate Cancer Patients with PSA Relapse

Hoffmann MA, von Eyben FE, Fischer N, Rosar F, Müller-Hübenthal J, Buchholz HG, Wieler HJ, Schreckenberger M (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Cancers MDPI

Book Volume: 14

Article Number: 1479

Journal Issue: 6

DOI: 10.3390/cancers14061479

Abstract

This study aimed to compare the diagnostic performance of [¹⁸F]PSMA-1007 positron emission tomography/computed tomography (PET/CT) (¹⁸F-PSMA) and [⁶⁸Ga]Ga-PSMA-11 PET/CT (⁶⁸Ga-PSMA) by identifying prostate-specific antigen (PSA) threshold levels for optimal detecting recurrent prostate cancer (PC) and to compare both methods. Retrospectively, the study included 264 patients. The performances of¹⁸F-PSMA and⁶⁸Ga-PSMA in relation to the pre-scan PSA were assessed by receiver operating characteristic (ROC) curve.¹⁸F-PSMA showed PC-lesions in 87.5% (112/128 patients), while⁶⁸Ga-PSMA identified them in 88.9% (121/136). For¹⁸F-PSMA biochemical recurrent (BCR) patients treated with radical prostatectomy (78/128, patient group: F-RP), a PSA of 1.08 ng/mL was found to be the optimal cut-off level for predicting positive and negative scans (AUC = 0.821; 95%, CI: 0.710–0.932), while for prostatectomized⁶⁸Ga-PSMA BCR-patients (89/136, patient group: Ga-RP), the cut-off was 1.84 ng/mL (AUC = 0.588; 95%, CI: 0.410–0.766). In patients with PSA < 1.08 ng/mL (F-RP) 76.3% and <1.84 ng/mL (Ga-RP) 78.6% scans were positive, whereas patients with PSA ≥ 1.08 ng/mL (F-RP) or 1.84 ng/mL (Ga-RP) had positive scan results in 100% and 91.5% (p < 0.001/p = 0.085). The identified PSA thresholds for PSMA-mappable PC lesions in BCR-patients (RP) showed a better separation for¹⁸F-PSMA with regard to the distinguishing of positive and negative PC-lesions compared to⁶⁸Ga-PSMA. However, the two PSMA PET/CT tracers gave similar overall findings.

Involved external institutions

Bundesministerium der Verteidigung / Bundeswehr

Germany (DE) Universität zu Köln

Germany (DE) Universitätsklinikum des Saarlandes (UKS)

Germany (DE) Praxis im KölnTriangle

Germany (DE) Johannes Gutenberg-Universität Mainz (JGU)

Germany (DE) Medical Center Düsseldorf

Germany (DE)

How to cite

APA:

Hoffmann, M.A., von Eyben, F.E., Fischer, N., Rosar, F., Müller-Hübenthal, J., Buchholz, H.G.,... Schreckenberger, M. (2022). Comparison of [18F]PSMA-1007 with [68Ga]Ga-PSMA-11 PET/CT in Restaging of Prostate Cancer Patients with PSA Relapse. Cancers, 14(6). https://doi.org/10.3390/cancers14061479

MLA:

Hoffmann, Manuela A., et al. "Comparison of [18F]PSMA-1007 with [68Ga]Ga-PSMA-11 PET/CT in Restaging of Prostate Cancer Patients with PSA Relapse." Cancers 14.6 (2022).

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