Addition of Standard Enzalutamide Medication Shows Synergistic Effects on Response to [177 Lu]Lu-PSMA-617 Radioligand Therapy in mCRPC Patients with Imminent Treatment Failure—Preliminary Evidence of Pilot Experience
Rosar F, Bader H, Bartholomä M, Maus S, Burgard C, Linxweiler J, Khreish F, Ezziddin S (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 14
Article Number: 2691
Journal Issue: 11
Abstract
Well-received strong efficacy of prostate-specific membrane antigen (PSMA)-targeted ra-dioligand therapy (RLT) does not prevent patients from either early or eventual disease progression under this treatment. In this study, we investigated co-medication with enzalutamide as a potential re-sensitizer for PSMA-RLT in patients with imminent treatment failure on standard177Lu-based PSMA-RLT. Ten mCRPC patients who exhibited an insufficient response to conventional [177Lu]Lu-PSMA-617 RLT received oral medication of enzalutamide 160 mg/d as an adjunct to continued PSMA-RLT. Prostate-specific antigen (PSA) and standard toxicity screening lab work-up were performed to assess the treatment efficacy and safety in these individuals. The mean PSA increase under PSMA-RLT before starting the re-sensitizing procedure was 22.4 ± 26.5%. After the introduction of enzalutamide medication, all patients experienced a PSA decrease, –43.4 ± 20.0% and –48.2 ± 39.0%, after one and two cycles of enzalutamide-augmented PSMA-RLT, respectively. A total of 70% of patients (7/10) experienced partial remission, with a median best PSA response of –62%. Moreover, 5/6 enzalutamide-naïve patients and 2/4 patients who had previously failed enzalutam-ide exhibited a partial remission. There was no relevant enzalutamide-induced toxicity observed in this small cohort. This pilot experience suggests the synergistic potential of adding enzalutamide to PSMA-RLT derived from the intra-individual comparison of177Lu-based PSMA-RLT ± enzalutam-ide.
Involved external institutions
Germany (DE)How to cite
APA:
Rosar, F., Bader, H., Bartholomä, M., Maus, S., Burgard, C., Linxweiler, J.,... Ezziddin, S. (2022). Addition of Standard Enzalutamide Medication Shows Synergistic Effects on Response to [177 Lu]Lu-PSMA-617 Radioligand Therapy in mCRPC Patients with Imminent Treatment Failure—Preliminary Evidence of Pilot Experience. Cancers, 14(11). https://doi.org/10.3390/cancers14112691
MLA:
Rosar, Florian, et al. "Addition of Standard Enzalutamide Medication Shows Synergistic Effects on Response to [177 Lu]Lu-PSMA-617 Radioligand Therapy in mCRPC Patients with Imminent Treatment Failure—Preliminary Evidence of Pilot Experience." Cancers 14.11 (2022).
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