Primary Staging of Prostate Cancer Patients with [18F]PSMA-1007 PET/CT Compared with [68Ga]Ga-PSMA-11 PET/CT

Hoffmann MA, Müller-Hübenthal J, Rosar F, Fischer N, von Eyben FE, Buchholz HG, Wieler HJ, Schreckenberger M (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Journal of Clinical Medicine MDPI

Book Volume: 11

Article Number: 5064

Journal Issue: 17

DOI: 10.3390/jcm11175064

Abstract

Background: Hybrid imaging with prostate-specific membrane antigen (PSMA) is gaining importance as an increasingly meaningful tool for prostate cancer (PC) diagnostics and as a guide for therapy decisions. This study aims to investigate and compare the performance of [18F]PSMA-1007 (18F-PSMA) and [68Ga]Ga-PSMA-11 positron emission tomography/computed tomography (68Ga-PSMA) in the initial staging of PC patients. Methods: The data of 88 biopsy-proven patients were retrospectively evaluated. PSMA-avid lesions were compared with the histopathologic Gleason Score (GS) for prostate biopsies, and the results were plotted by receiver operating characteristic (ROC)-curve. Optimal maximum standardized uptake value (SUVmax) cut-off values were rated using the Youden index. Results: 18F-PSMA was able to distinguish GS ≤ 7a from ≥7b with a sensitivity of 62%, specificity of 85%, positive predictive value (PPV) of 92%, and accuracy of 67% for a SUVmax of 8.95, whereas sensitivity was 54%, specificity 91%, PPV 93%, and accuracy 66% for 68Ga-PSMA (SUVmax 8.7). Conclusions: Both methods demonstrated a high concordance of detected PSMA-avid lesions with histopathologically proven PC. 18F-PSMA and 68Ga-PSMA are both suitable for the characterization of primary PC with a comparable correlation of PSMA-avid lesions with GS. Neither method showed a superior advantage. Our calculated SUVmax thresholds may represent valuable parameters in clinical use to distinguish clinically significant PC (csPC) from non-csPC.

Involved external institutions

Bundesministerium der Verteidigung / Bundeswehr DE Germany (DE) Universitätsklinikum des Saarlandes (UKS) DE Germany (DE) Klinikum Leverkusen DE Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) DE Germany (DE) Medical Center Düsseldorf DE Germany (DE)

How to cite

APA:

Hoffmann, M.A., Müller-Hübenthal, J., Rosar, F., Fischer, N., von Eyben, F.E., Buchholz, H.G.,... Schreckenberger, M. (2022). Primary Staging of Prostate Cancer Patients with [18F]PSMA-1007 PET/CT Compared with [68Ga]Ga-PSMA-11 PET/CT. Journal of Clinical Medicine, 11(17). https://doi.org/10.3390/jcm11175064

MLA:

Hoffmann, Manuela A., et al. "Primary Staging of Prostate Cancer Patients with [18F]PSMA-1007 PET/CT Compared with [68Ga]Ga-PSMA-11 PET/CT." Journal of Clinical Medicine 11.17 (2022).

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