Histopathological Confirmed Polycythemia Vera with Transformation to Myelofibrosis Depicted on [18F]FDG PET/CT
Bastian MB, Blickle A, Burgard C, Fleser O, Christofyllakis K, Ezziddin S, Rosar F (2024)
Publication Type: Journal article
Publication year: 2024
Journal
Book Volume: 14
Article Number: 982
Journal Issue: 10
DOI: 10.3390/diagnostics14100982
Abstract
We present a case of a 59-year-old male diagnosed with polycythemia vera (PV) for many years, who presented with a relatively abrupt onset of heavy constitutional symptoms, including fatigue, night sweats, and a 10% weight loss over 6 weeks. Despite the known initial diagnosis of PV, the presence of profound B-symptoms prompted further investigation. A positron emission tomography/computed tomography (PET/CT) scan with 18F-Fluorodeoxyglucose ([18F]FDG) was performed to exclude malignant diseases. The [18F]FDG PET/CT revealed intense metabolic activity in the bone marrow of the proximal extremities and trunk skeleton, as well as a massively enlarged spleen with increased metabolic activity. Histopathologically, a transformation to myelofibrosis was revealed on a bone marrow biopsy. The case intends to serve as an exemplification for [18F]FDG PET/CT in PV with transformation to myelofibrosis (post-PV myelofibrosis).
Involved external institutions
Germany (DE)How to cite
APA:
Bastian, M.B., Blickle, A., Burgard, C., Fleser, O., Christofyllakis, K., Ezziddin, S., & Rosar, F. (2024). Histopathological Confirmed Polycythemia Vera with Transformation to Myelofibrosis Depicted on [18F]FDG PET/CT. Diagnostics, 14(10). https://doi.org/10.3390/diagnostics14100982
MLA:
Bastian, Moritz B., et al. "Histopathological Confirmed Polycythemia Vera with Transformation to Myelofibrosis Depicted on [18F]FDG PET/CT." Diagnostics 14.10 (2024).
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