Harnessing Terbium Radioisotopes for Clinical Advancements: A Systematic Review
Abdlkadir AS, Rosar F, Jalilian A, Moghrabi S, Al-Balooshi B, Rabei O, Kairemo K, Al-Ibraheem A (2025)
Publication Type: Journal article, Review article
Publication year: 2025
Journal
Book Volume: 59
Pages Range: 50-61
Article Number: i4919
Journal Issue: 1
DOI: 10.1007/s13139-024-00891-0
Abstract
Background this systematic review was conducted to assess the practical application of terbium radioisotopes, utilizing systematic search methodologies to identify relevant studies. Methods the databases of PubMed, Web of Science, and Scopus were systematically scoured, targeting the research on four terbium isotopes: 149 Tb, 152 Tb, 155 Tb, and 161 Tb. Various combinations of keywords related to terbium and its four radioisotopes were used in the search process. The search encompassed studies conducted up to July 27, 2024. Results following the removal of 335 duplicate research articles, a cohort of 429 papers was curated for potential inclusion in the study. Out of 429 articles reviewed, a mere nine addressed the potential uses of 161 Tb and 152 Tb. Notably, 155 Tb and 149 Tb have yet to be examined in human subjects. Conclusions the research trajectory is now veering towards clinical studies that provide in-human data, with the goal of advancing radiotheranostics and nuclear oncology. The preliminary outcomes are stimulating and have led to the initiation of several clinical trials. The success of these trials and the establishment of production facilities will be critical for the clinical adoption of these agents.
Involved external institutions
King Hussein Cancer Center (KHCC) / مركز الحسين للسرطان
Jordan (JO)
Universitätsklinikum des Saarlandes (UKS)
Germany (DE)
International Atomic Energy Agency (IAEA)
Austria (AT)
Dubai Health Authority (DHA)
United Arab Emirates (AE)
Jordan (JO)
Universitätsklinikum des Saarlandes (UKS)
Germany (DE)
International Atomic Energy Agency (IAEA)
Austria (AT)
Dubai Health Authority (DHA)
United Arab Emirates (AE)
How to cite
APA:
Abdlkadir, A.S., Rosar, F., Jalilian, A., Moghrabi, S., Al-Balooshi, B., Rabei, O.,... Al-Ibraheem, A. (2025). Harnessing Terbium Radioisotopes for Clinical Advancements: A Systematic Review. Nuclear Medicine and Molecular Imaging, 59(1), 50-61. https://doi.org/10.1007/s13139-024-00891-0
MLA:
Abdlkadir, Ahmed Saad, et al. "Harnessing Terbium Radioisotopes for Clinical Advancements: A Systematic Review." Nuclear Medicine and Molecular Imaging 59.1 (2025): 50-61.
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