What is the best path towards allogeneic transplantation in MDS and AML? A survey among German-spreaking centers for allogeneic hematopoietic stem cell transplantation.
Krause S, Bethge W, Bug G, Elmaagacli A, Jost E, Klein SA, Kobbe G, Kraus S, Krüger WH, Luft T, Müller LP, Schäfer-Eckart K, Schetelig J, Steiner N, Stelljes M, Tischer J, Winkler J, Wolff D, Wortmann F, Röllig C (2026)
Publication Type: Journal article
Publication year: 2026
Journal
Book Volume: 105
Journal Issue: 7
DOI: 10.1007/s00277-026-07115-9
Abstract
Allogeneic hematopoetic stem cell transplantation (allo SCT) is a treatment option with a unique chance of cure for patients with high-risk AML or MDS. However, the optimal path for an individual patient on its way to allo SCT is far from clear and subject of ongoing debates. Upfront transplantation "as soon as possible" competes with strategies to achieve deep remission or at least stabilization of the disease. In this context, we performed a survey among German transplant centers to assess their preferred strategies for patients before SCT in five typical scenarios of AML and MDS. We obtained replies from 22 centers, revealing a heterogenous use of possible strategies. Upfront transplantation was a preferred option (68%) in intermediate risk MDS, chemotherapy was preferred (64%) as bridging for AML in remission, whereas hypomethylating agents (HMA) and induction chemotherapy for relapsed AML were highly controversial. Further prospective evaluation of different options is desirable.
Authors with CRIS profile
Stefan Krause
Department of Medicine 5 – Haematology and Oncology
Julia Winkler
Department of Medicine 5 – Haematology and Oncology
Involved external institutions
Klinikum Nürnberg
Germany (DE)
Universitätsklinikum Carl Gustav Carus Dresden
Germany (DE)
Medizinische Universität Innsbruck
Austria (AT)
Universitätsklinikum Regensburg
Germany (DE)
Universitätsklinikum Schleswig-Holstein (UKSH)
Germany (DE)
Universitätsklinikum Münster
Germany (DE)
Klinikum der Universität München (LMU Klinikum)
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
Asklepios Kliniken
Germany (DE)
Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
Germany (DE)
Universitätsklinikum Mannheim / University Medical Centre Mannheim (Universitätsmedizin Mannheim)
Germany (DE)
Universitätsklinikum Düsseldorf
Germany (DE)
Universitätsklinikum Würzburg
Germany (DE)
Universitätsmedizin Greifswald / Universitätsklinikum Greifswald
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Universitätsklinikum Halle (Saale)
Germany (DE)
Germany (DE)
Universitätsklinikum Carl Gustav Carus Dresden
Germany (DE)
Medizinische Universität Innsbruck
Austria (AT)
Universitätsklinikum Regensburg
Germany (DE)
Universitätsklinikum Schleswig-Holstein (UKSH)
Germany (DE)
Universitätsklinikum Münster
Germany (DE)
Klinikum der Universität München (LMU Klinikum)
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
Asklepios Kliniken
Germany (DE)
Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
Germany (DE)
Universitätsklinikum Mannheim / University Medical Centre Mannheim (Universitätsmedizin Mannheim)
Germany (DE)
Universitätsklinikum Düsseldorf
Germany (DE)
Universitätsklinikum Würzburg
Germany (DE)
Universitätsmedizin Greifswald / Universitätsklinikum Greifswald
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Universitätsklinikum Halle (Saale)
Germany (DE)
How to cite
APA:
Krause, S., Bethge, W., Bug, G., Elmaagacli, A., Jost, E., Klein, S.A.,... Röllig, C. (2026). What is the best path towards allogeneic transplantation in MDS and AML? A survey among German-spreaking centers for allogeneic hematopoietic stem cell transplantation. Annals of Hematology, 105(7). https://doi.org/10.1007/s00277-026-07115-9
MLA:
Krause, Stefan, et al. "What is the best path towards allogeneic transplantation in MDS and AML? A survey among German-spreaking centers for allogeneic hematopoietic stem cell transplantation." Annals of Hematology 105.7 (2026).
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