Medical treatment of osteoporosis in osteoporotic vertebral fractures - Results from the prospective EOFTT multicenter study

Schenk P, Wiedemann J, Schnake KJ, Spiegl UJ, Katscher S, Bäumlein M, Zimmermann V, Schmeiser G, Scherer MA, Müller M, Liepold K, Sprengel K, Schramm S, Baron C, Osterhoff G, Franck A, Scheyerer MJ, Ullrich B, Schwarz F (2026)

Publication Type: Journal article

Publication year: 2026

Journal

Brain and Spine Elsevier

Book Volume: 6

Article Number: 106127

DOI: 10.1016/j.bas.2026.106127

Abstract

Introduction: Osteoporotic medication (oTh) is essential for secondary prevention but is often not prescribed after vertebral fractures. Research question: The aim of this analysis was to assess the status of oTh in inpatients with osteoporotic thoracolumbar fractures and to analyze possible supply gaps. Materials and methods: Data were collected as part of the multicenter, prospective EOFTT (Evaluation of the Osteoporotic Fracture Classification, Treatment Score and Therapy Recommendations) study. A total of 518 patients with osteoporotic thoracolumbar fractures in 17 clinics were included. The presence, type, and changes over time of oTh were recorded and evaluated using the Cochrane Q test. Results: Hospitalisation increased oTh with 36% at admission significantly in women to 83%, and in men to 71% (p < 0.001). At admission women received more frequently oTh than men (p = 0.017). At the follow-up after 7 ± 5 months, there was no significant differences between the sexes (p = 0.330). However, the proportion in both groups decreased significantly to 41% (women) and 34% (men), respectively (p < 0.001). In-hospital treatment led to a significant increase in the initiation of anti-osteoporotic medication, with calcium and vitamin D supplementation rising from 13% at admission to 35% at discharge (p < 0.001). However, a substantial and significant decline was observed during follow-up (18%, p < 0.001). Discussion and conclusion: In the inpatient setting, there is a clear improvement in oTh, which is particularly pronounced in female patients. However, the significant decline in therapy rates at follow-up highlights deficits in long-term care. Despite existing recommendations, evidence-based agents such as bisphosphonates or osteoanabolic are still rarely used. This indicates a relevant gap in care in secondary prevention and underscores the need for structured, post-hospitalisation concepts for sustainable osteoporosis therapy.

Authors with CRIS profile

Simon Schramm Department of Orthopaedic and Trauma Surgery

Involved external institutions

Sana Kliniken AG DE Germany (DE) Universitätsklinikum Gießen und Marburg (UKGM) DE Germany (DE) Kliniken Südostbayern AG DE Germany (DE) Schön Klinik Hamburg Eilbek DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) DE Germany (DE) Friedrich-Schiller-Universität Jena DE Germany (DE) Universität Luzern / University of Lucerne (UNILU) CH Switzerland (CH) Berufsgenossenschaftliche Unfallklinik Tübingen (BGU) DE Germany (DE) Unfallkrankenhaus Berlin DE Germany (DE) Klinikum Coburg DE Germany (DE) Universitätsklinikum Düsseldorf DE Germany (DE) Universitätsklinikum Jena DE Germany (DE) Berufsgenossenschaftlichen Kliniken Bergmannstrost Halle DE Germany (DE) Krankenhaus Dresden-Friedrichstadt, Städtisches Klinikum DE Germany (DE)

How to cite

APA:

Schenk, P., Wiedemann, J., Schnake, K.J., Spiegl, U.J., Katscher, S., Bäumlein, M.,... Schwarz, F. (2026). Medical treatment of osteoporosis in osteoporotic vertebral fractures - Results from the prospective EOFTT multicenter study. Brain and Spine, 6. https://doi.org/10.1016/j.bas.2026.106127

MLA:

Schenk, Philipp, et al. "Medical treatment of osteoporosis in osteoporotic vertebral fractures - Results from the prospective EOFTT multicenter study." Brain and Spine 6 (2026).

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