Synthesis and Evaluation of Novel Sulfonamido-oxine (Sox)-Substituted Lysine Derivatives

Kuschow M, Kuhn J, Drees LJ, Schuster LS, Osterloh V, Heinrich M (2026)

Publication Type: Journal article

Publication year: 2026

Journal

Synthesis-Stuttgart Thieme Publishing / Georg Thieme Verlag

Abstract

Functional peptides containing strongly coordinating sites for metal ions in combination with fluorescent properties represent valuable tools for diverse applications, most notably as activity sensors for protein kinases and phosphatases or more generally for the complexation of diverse metal ions. Herein, the synthesis and photophysical characterization of two novel sulfonamido-oxine (Sox)-substituted lysines are described. Due to their straightforward availability, applicability in solid phase peptide synthesis, and useful zinc(II)-binding properties of the chelating unit, these compounds are now available for a broad range of applications.

Authors with CRIS profile

Meret Kuschow Lehrstuhl für Pharmazeutische Chemie Jakob Kuhn Professur für Pharmazeutische Chemie Luca Janik Drees Lehrstuhl für Pharmazeutische Chemie Luca Sophie Schuster Lehrstuhl für Pharmazeutische Chemie Vanessa Osterloh Professur für Pharmazeutische Chemie Markus Heinrich Professur für Pharmazeutische Chemie

How to cite

APA:

Kuschow, M., Kuhn, J., Drees, L.J., Schuster, L.S., Osterloh, V., & Heinrich, M. (2026). Synthesis and Evaluation of Novel Sulfonamido-oxine (Sox)-Substituted Lysine Derivatives. Synthesis-Stuttgart. https://doi.org/10.1055/a-2872-0385

MLA:

Kuschow, Meret, et al. "Synthesis and Evaluation of Novel Sulfonamido-oxine (Sox)-Substituted Lysine Derivatives." Synthesis-Stuttgart (2026).

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