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Efficacy and safety of oliceridine in daytime hysteroscopic polypectomy: a randomized, double-blind, single-center controlled trial

Wang Y, Qiu Y, Wang L, Kang J, Zhang W, Khare P, Song X (2026)

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Publication Type: Journal article

Publication year: 2026

Journal

Book Volume: 13

Article Number: 1819353

DOI: 10.3389/fmed.2026.1819353

Abstract

Background – This study aimed to compare the effects of oliceridine, fentanyl, and sufentanil on early recovery and perioperative safety during hysteroscopic polypectomy. Methods – A single-center, double-blind, randomized controlled trial enrolled 92 patients aged 18–65 with ASA I–II and BMI 18–30 kg/m² undergoing elective intravenous general anesthesia for the procedure. Patients were randomly assigned in a 1:1:1 ratio to the fentanyl (n = 30), sufentanil (n = 31), and oliceridine (n = 31) groups. The primary outcome was the Clinical Recovery Score (CRS) at 5, 10, and 15 min post-awakening. Secondary outcomes included time to eye opening on verbal command, time to full awakening, intraoperative vital signs, and adverse events. Results – The oliceridine group had significantly higher CRS at 5, 10, and 15 min after awakening than the fentanyl and sufentanil groups (overall p = 0.002, p = 0.009, and p < 0.001, respectively). The time to eye opening on verbal command was shorter in the oliceridine group than in the fentanyl and sufentanil groups (overall p < 0.001). The time to full awakening was also shorter in the oliceridine group than in the fentanyl and sufentanil groups (overall p < 0.001). At T2 (after anesthetic stabilization and before surgery), the oliceridine group had higher RR than the fentanyl and sufentanil groups (both p < 0.001), and higher SpO2 than the fentanyl group (p = 0.0178). No significant differences were observed among the groups in intraoperative motor response, assisted ventilation, or rescue analgesic use. Conclusion – For hysteroscopic polypectomy, propofol combined with oliceridine was associated with improved early recovery outcomes and more favorable respiratory-related observations compared with fentanyl and sufentanil. These findings support the potential value of oliceridine in facilitating earlier recovery in day surgery, although confirmation in larger studies with more comprehensive physiological monitoring is required.

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How to cite

APA:

Wang, Y., Qiu, Y., Wang, L., Kang, J., Zhang, W., Khare, P., & Song, X. (2026). Efficacy and safety of oliceridine in daytime hysteroscopic polypectomy: a randomized, double-blind, single-center controlled trial. Frontiers in Medicine, 13. https://doi.org/10.3389/fmed.2026.1819353

MLA:

Wang, Yuan, et al. "Efficacy and safety of oliceridine in daytime hysteroscopic polypectomy: a randomized, double-blind, single-center controlled trial." Frontiers in Medicine 13 (2026).

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