Elevated caspase 3 expression correlates with severe inflammation in Crohn’s disease
Sejdiu N, Naumann M, Vieth M (2026)
Publication Type: Journal article
Publication year: 2026
Journal
Book Volume: 70
Article Number: 4570
Journal Issue: 2
Abstract
Caspase 3 is a key executioner of apoptotic cell death and contributes to intestinal epithelial homeodynamics. Apoptotic dysregulation has been implicated in Crohn’s disease, yet data on caspase 3 expression across disease activity states remain limited. This study analyzed caspase 3 expression in intestinal biopsies from Crohn’s disease patients. Paraffin-embedded biopsies from 289 individuals were examined, including active disease (mild and severe inflammation), upper gastrointestinal involvement, remission and non-inflamed tissue. Expression in epithelial and immune cells was assessed by immunohistochemistry and scored using the Remmele immunoreactive score (IRS). Caspase 3 expression levels in epithelial cells increased in cases of severe inflammation (p=0.012), and immune cells exhibited even more pronounced expression levels (p<0.001). These findings suggest that caspase 3 expression in epithelial and immune cells may help to distinguish between mild and severe inflammation.
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Germany (DE)How to cite
APA:
Sejdiu, N., Naumann, M., & Vieth, M. (2026). Elevated caspase 3 expression correlates with severe inflammation in Crohn’s disease. European Journal of Histochemistry, 70(2). https://doi.org/10.4081/ejh.2026.4570
MLA:
Sejdiu, Nafie, Michael Naumann, and Michael Vieth. "Elevated caspase 3 expression correlates with severe inflammation in Crohn’s disease." European Journal of Histochemistry 70.2 (2026).
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