Zarzor MS, Budday S (2026)
Publication Type: Authored book
Publication year: 2026
Publisher: Elsevier
ISBN: 9780443273810
DOI: 10.1016/B978-0-443-27380-3.00052-X
Brain development is a complex process that involves a precisely orchestrated sequence of genetic, biochemical, and physical events. At the cellular scale, different types of progenitor cells divide to eventually produce neurons that then migrate toward the brain surface to form the cortex. At the organ scale, physical forces play a central role in translating these cellular mechanisms into the complex surface morphology of the human brain. Only by considering cell biological, genetic, and mechanical aspects simultaneously, will we be able to fully understand the complex process of brain development. In this Chapter, we summarize the mechanical aspects of early brain development, neurogenesis, and cortical folding. We highlight how computational modeling can help understand the link between cellular processes during brain development and cortical folding. In addition, we discuss the role of mechanics for cortical malformation.
APA:
Zarzor, M.S., & Budday, S. (2026). Mechanics in nervous system development. Elsevier.
MLA:
Zarzor, Mohammad Saeed, and Silvia Budday. Mechanics in nervous system development. Elsevier, 2026.
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