T-cell engagers mediate deep cell depletion beyond autoimmunity

Kurzhagen J, Laqua W, Schiffer M, Grieshaber Bouyer R (2026)

Publication Type: Journal article

Publication year: 2026

Journal

Kidney International Nature Publishing Group: Open Access Hybrid Model Option A

Book Volume: 109

Pages Range: 1081-1084

Journal Issue: 6

DOI: 10.1016/j.kint.2026.03.010

Abstract

Deep B-cell and plasma cell depletion is rapidly reshaping the therapeutic landscape. Initially developed for hematologic malignancies, T cell–redirecting therapies (chimeric antigen receptor T cells and T-cell engagers) are now demonstrating profound efficacy in autoimmune diseases. The first successful application of a B-cell maturation antigen–targeting T-cell engager to achieve human leukocyte antigen desensitization in a highly sensitized kidney transplant candidate marks yet another critical milestone: This success signals a “spillover” of deep cell depletion into nonmalignant, nonautoimmune indications and paves the way for novel strategies in transplantation tolerance, severe allergic diseases, and beyond.

Authors with CRIS profile

Johanna Kurzhagen Department of Medicine 4 – Nephrology and Hypertension William Laqua Department of Medicine 4 – Nephrology and Hypertension Mario Schiffer Lehrstuhl für Innere Medizin IV Ricardo Grieshaber Bouyer Department of Medicine 3 – Rheumatology and Immunology

How to cite

APA:

Kurzhagen, J., Laqua, W., Schiffer, M., & Grieshaber Bouyer, R. (2026). T-cell engagers mediate deep cell depletion beyond autoimmunity. Kidney International, 109(6), 1081-1084. https://doi.org/10.1016/j.kint.2026.03.010

MLA:

Kurzhagen, Johanna, et al. "T-cell engagers mediate deep cell depletion beyond autoimmunity." Kidney International 109.6 (2026): 1081-1084.

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