Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology
Carta MG, Tögel L, Hölsken A, Schubart C, Sticht H, Stöhr R, Spörl S, Meidenbauer N, Hartmann A, Magni P, Haller F, Ferrazzi F (2026)
Publication Type: Journal article
Publication year: 2026
Journal
Book Volume: 28
Pages Range: 469-484
Journal Issue: 6
DOI: 10.1016/j.jmoldx.2026.03.004
Abstract
Key Points • Accurate oncogenicity classification is crucial, but it remains inconsistent across institutions. • No tools currently automate all the guidelines for standardized oncogenicity classification. • Oncogenicity Variant Interpreter (OncoVI) automates the evaluation of oncogenicity guidelines using public reference resources. • OncoVI enables consistent oncogenicity classification and promotes guideline adoption.
Authors with CRIS profile
Maria Giulia Carta
Institute of Pathology
Lars Tögel
Institute of Pathology
Annett Hölsken
Institute of Pathology
Christoph Schubart
Institute of Pathology
Heinrich Sticht
Professur für Bioinformatik
Robert Stöhr
Institute of Pathology
Silvia Spörl
Department of Medicine 5 – Haematology and Oncology
Norbert Meidenbauer
Department of Medicine 5 – Haematology and Oncology
Arndt Hartmann
Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie
Florian Haller
Institute of Pathology
Fulvia Ferrazzi
Department of Nephropathology
Involved external institutions
Italy (IT)How to cite
APA:
Carta, M.G., Tögel, L., Hölsken, A., Schubart, C., Sticht, H., Stöhr, R.,... Ferrazzi, F. (2026). Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology. Journal of Molecular Diagnostics, 28(6), 469-484. https://doi.org/10.1016/j.jmoldx.2026.03.004
MLA:
Carta, Maria Giulia, et al. "Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology." Journal of Molecular Diagnostics 28.6 (2026): 469-484.
BibTeX: Download