Additional Crypt Phenotypes Lined With High-Grade Cellular Dysplasia in Protruding Growths in Ulcerative Colitis

Rubio CA, Firmbach D, Matek C, Vieth M, Lang-Schwarz C (2026)

Publication Type: Journal article

Publication year: 2026

Journal

Acta pathologica et microbiologica Scandinavica Blackwell Publishing Inc.

Book Volume: 134

Article Number: e70216

Journal Issue: 5

DOI: 10.1111/apm.70216

Abstract

Two crypt phenotypes (ACP): crypt rings in tandem (CRT) and crypts with lateral budding's (CLB's) were recently found interpolated amidst generally accepted crypt phenotypes (GACP, i.e., tubular, tubulovillous, villous and serrated). The frequency of cases with UC-PDG, with CRT and with CLB's in GACP and in UC-associated sporadic adenomas (UC-aspa) was recorded. The possibility that the presence of ACP could increase histological discrimination between UC-PDG and UC-aspa was also explored. Two hundred digitalized biopsy-cases were investigated: 100 with UC-PDG and 100 with UC-aspa. Six GACP and two types of cellular dysplasia: low-grade (LGD) and high-grade dysplasia (HGD) were found. CRT and CLB's were present in 66% of the 200 cases. A significantly higher number of cases with villous phenotype wihout or with HGD, with CLB's phenotype without or with HGD, and with tubulovillous phenotype with HGD were found in UC-PDG than in UC-asta. Several authors found no significant difference in the histological characteristics between UC-protruding dysplastic lesions and US-aspa. This work reveals, however, that the different number of cases with the above-mentioned histological parameters present in each group permitted to discriminate between UC-PDG and UC-asta.

Authors with CRIS profile

Daniel Firmbach Institute of Pathology Christian Matek Institute of Pathology Michael Vieth Institute of Pathology Corinna Lang-Schwarz Institut für Lehre und Forschung am Medizincampus Oberfranken (MCO)

Involved external institutions

Karolinska Institute SE Sweden (SE)

How to cite

APA:

Rubio, C.A., Firmbach, D., Matek, C., Vieth, M., & Lang-Schwarz, C. (2026). Additional Crypt Phenotypes Lined With High-Grade Cellular Dysplasia in Protruding Growths in Ulcerative Colitis. Acta pathologica et microbiologica Scandinavica, 134(5). https://doi.org/10.1111/apm.70216

MLA:

Rubio, Carlos A., et al. "Additional Crypt Phenotypes Lined With High-Grade Cellular Dysplasia in Protruding Growths in Ulcerative Colitis." Acta pathologica et microbiologica Scandinavica 134.5 (2026).

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