Reduction Based One-Step Synthesis of Vinyl Acetate Modified Poly(Lactic Acid) and Its Characterization

Mukta NA, Ahmed S, Chowdhury AMS, Haque P (2026)

Publication Type: Journal article

Publication year: 2026

DOI: 10.1002/vjch.70141

Abstract

Poly(lactic acid) (PLA) is a biodegradable, bioresorbable and hydrophobic synthetic polymer used in many commercial biomedical applications. In biomedical engineering, the hydrophobicity of polymers induces protein and lipid interactions, whereas hydrophilicity adds antifouling characteristics. This study focused on modifying commercial PLA using lithium tetrahydridoaluminate (LiAlH4) and vinyl acetate to reduce the hydrophobicity of PLA. From gel permeation chromatography and nuclear magnetic resonance (NMR) data, it is observed that around 4% of the vinyl groups used were grafted on the modified PLA. A new bond of C═C and an increase of ─C═O groups in the modified PLA are noticed from FTIR and NMR analyses. Increased Tg value suggests more crosslinking in the structures of modified PLA. Tm, crystallinity and crystallite sizes are also decreased due to modifications. The reduced average water contact angle (a decrease of 6° from pristine PLA) indicates a reduction in hydrophobicity of the PLA, which may arise from a more accessible amorphous polar region. Proposed modifications could provide alternative ways to synthesize PLA-based biomaterials applicable to tissue regeneration and the controlled release of bioactive molecules, where the hydrophobic-hydrophilic balance is a primary concern.

Involved external institutions

East West University BD Bangladesh (BD) Bangladesh Council of Scientific and Industrial Research (BCSIR) / বিসিএসআইআর গবেষণাগার BD Bangladesh (BD) University of Dhaka BD Bangladesh (BD)

How to cite

APA:

Mukta, N.A., Ahmed, S., Chowdhury, A.M.S., & Haque, P. (2026). Reduction Based One-Step Synthesis of Vinyl Acetate Modified Poly(Lactic Acid) and Its Characterization. . https://doi.org/10.1002/vjch.70141

MLA:

Mukta, Nasima Akter, et al. "Reduction Based One-Step Synthesis of Vinyl Acetate Modified Poly(Lactic Acid) and Its Characterization." (2026).

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