Design considerations and approaches for clinically approvable MPS/MPI SPIONs-the SEON concept-

Tietze R, Heinen L, Lyer S, Alexiou C (2026)

Publication Type: Journal article

Publication year: 2026

Journal

International Journal of Magnetic Particle Imaging Infinite Science Publishing

Book Volume: 12

Article Number: 2603035

Journal Issue: 1

DOI: 10.18416/ijmpi.2026.2603035

Abstract

The development of suitable magnetic nanoparticles as tracers for MPI faces multiple obstacles. Beyond MPI-specific optimization, properties that are of importance for clinical approval like biocompatibility, colloidal stability in blood, synthesis reproducibility and upscalability of the process have to be taken into account. Overcoming these challenges will require interdisciplinary efforts. The Section of Experimental Oncology and Nanomedicine (SEON) is dedicated to develop SPIONs that can be translated into clinical use. Together with partners from the pharmaceutical industry, we will also be capable of bringing such processes into preclinical and clinical trials.

Authors with CRIS profile

Rainer Tietze Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Lukas Heinen Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Stefan Lyer Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Christoph Alexiou Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik)

How to cite

APA:

Tietze, R., Heinen, L., Lyer, S., & Alexiou, C. (2026). Design considerations and approaches for clinically approvable MPS/MPI SPIONs-the SEON concept-. International Journal of Magnetic Particle Imaging, 12(1). https://doi.org/10.18416/ijmpi.2026.2603035

MLA:

Tietze, Rainer, et al. "Design considerations and approaches for clinically approvable MPS/MPI SPIONs-the SEON concept-." International Journal of Magnetic Particle Imaging 12.1 (2026).

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