Corte G, Atzinger A, Noversa de Sousa R, Mutlu MY, Temiz A, Bayat S, Raimondo MG, Ramming A, Sticherling M, Schmidkonz C, Kuwert T, Schett G, Tascilar K, Fagni F (2026)
Publication Type: Journal article
Publication year: 2026
Book Volume: 12
Journal Issue: 1
DOI: 10.1136/rmdopen-2025-006567
OBJECTIVES: To assess the clinical and imaging characteristics associated with fibroblast activation detected by 68Gallium-labelled fibroblast activation protein inhibitor positron emission tomography/CT (68Ga-FAPI-PET/CT) in patients with psoriasis and whether 68Ga-FAPI uptake correlates with the risk of progression to psoriatic arthritis (PsA). METHODS: Psoriasis patients with arthralgia underwent 68Ga-FAPI-PET/CT and were followed up prospectively. 68Ga-FAPI uptake was assessed at 71 articular sites and patients with ≥1 joint with 68Ga-FAPI uptake and PET/CT Joint Index≥2 were considered FAPI positive. The associations between FAPI uptake and clinical and ultrasound (US) findings were investigated. Survival analyses were conducted to assess the association between 68Ga-FAPI uptake and progression to PsA. RESULTS: 45 patients with psoriasis were enrolled, 37 of whom (82%) were FAPI positive. FAPI-positive psoriasis patients had significantly higher body mass index (BMI) (p=0.036) and Disease Activity Score 28-C reactive protein (p=0.033) compared with FAPI-negative patients. 68Ga-FAPI uptake was most frequent in large joints and mechanically stressed sites and was more likely in the presence of low-grade synovial hyperplasia (OR: 1.77, 95% CI 1.08 to 2.89), entheseal Power Doppler (OR: 3.80, 95% CI 1.66 to 8.72) and concomitant osteoarthritis (OA). FAPI-positive patients showed a higher risk of progression to PsA compared with FAPI-negative patients (HR 7.1, 95% CI 0.9 to 53.6) (log-rank p=0.028). Only 1/8 patients with psoriasis (12.5%) without 68Ga-FAPI uptake developed PsA, as opposed to 18/37 (49%) of FAPI-positive patients. CONCLUSIONS: In psoriasis patients with arthralgia, 68Ga-FAPI uptake, indicating fibroblast activation, is associated with higher BMI, more pain, subclinical US changes and concomitant OA. Pathological 68Ga-FAPI uptake at articular sites was indicative of higher risk of progression to PsA in our cohort, suggesting fibroblast activation as a crucial step to develop PsA.
APA:
Corte, G., Atzinger, A., Noversa de Sousa, R., Mutlu, M.Y., Temiz, A., Bayat, S.,... Fagni, F. (2026). Increased synovial and entheseal fibroblast activation detected by 68Ga-FAPI-PET/CT is associated with the development of psoriatic arthritis in psoriasis patients with arthralgia. RMD Open, 12(1). https://doi.org/10.1136/rmdopen-2025-006567
MLA:
Corte, Giulia, et al. "Increased synovial and entheseal fibroblast activation detected by 68Ga-FAPI-PET/CT is associated with the development of psoriatic arthritis in psoriasis patients with arthralgia." RMD Open 12.1 (2026).
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