INCIDENCE AND ENLARGEMENT RATE OF MYOPIC MACULAR NEOVASCULARIZATION-RELATED ATROPHY IN HIGHLY MYOPIC EYES

Moukadem O, Motloch K, Couanon M, Gaucher D, Philippakis E, Couturier A (2026)

Publication Type: Journal article

Publication year: 2026

Journal

Retina-The Journal of Retinal and Vitreous Diseases Lippincott, Williams & Wilkins

Book Volume: 46

Pages Range: 622-629

Journal Issue: 4

DOI: 10.1097/IAE.0000000000004731

Abstract

PURPOSE: To investigate the incidence and enlargement rate of myopic macular neovascularization (MNV)-related atrophy in highly myopic eyes. METHODS: This retrospective observational study included highly myopic eyes treated for myopic MNV followed for ≥24 months. Atrophy was defined as a retinal pigment epithelium disruption with hypertransmission on spectral-domain optical coherence tomography. The atrophic area detected on spectral-domain optical coherence tomography was delineated manually on en-face infrared images and measured with a built-in feature. Only eyes with tessellated fundus or diffuse atrophy at baseline were included. Eyes with preexisting retinal pigment epithelium atrophy, including patchy/MNV-related atrophy, were excluded. RESULTS: Among 473 MNV eyes, 44 eyes of 40 patients (mean follow-up: 75.4 ± 37.7 months) met the inclusion criteria. Fifteen eyes (34.1%) developed MNV-related atrophy 23.37 ± 18.02 months after MNV onset. The atrophy area increased from 0.38 ± 0.67 mm 2 at diagnosis to 1.08 ± 1.45 mm 2 after 45.77 ± 26.45 months ( P = 0.011), corresponding to an enlargement rate of 0.22 ± 0.25 mm 2 /year. Larger MNV diameter and male gender were associated with MNV-related atrophy development. CONCLUSION: In highly myopic eyes without preexisting retinal pigment epithelium atrophy, one third showed MNV-related atrophy within 2 years of MNV onset. The atrophy enlargement rate was 0.22 ± 0.25 mm 2 /year, highlighting the importance of close monitoring.

Involved external institutions

Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal FR France (FR)

How to cite

APA:

Moukadem, O., Motloch, K., Couanon, M., Gaucher, D., Philippakis, E., & Couturier, A. (2026). INCIDENCE AND ENLARGEMENT RATE OF MYOPIC MACULAR NEOVASCULARIZATION-RELATED ATROPHY IN HIGHLY MYOPIC EYES. Retina-The Journal of Retinal and Vitreous Diseases, 46(4), 622-629. https://doi.org/10.1097/IAE.0000000000004731

MLA:

Moukadem, Omar, et al. "INCIDENCE AND ENLARGEMENT RATE OF MYOPIC MACULAR NEOVASCULARIZATION-RELATED ATROPHY IN HIGHLY MYOPIC EYES." Retina-The Journal of Retinal and Vitreous Diseases 46.4 (2026): 622-629.

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