Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia

Kittel-Schneider S, Wobrock T, Scherk H, Schneider-Axmann T, Trost S, Zilles D, Wolf C, Schmitt A, Malchow B, Hasan A, Backens M, Reith W, Falkai P, Gruber O, Reif A (2015)

Publication Type: Journal article

Publication year: 2015

Journal

European archives of psychiatry and clinical neuroscience Springer Verlag (Germany)

Book Volume: 265

Pages Range: 127-136

Journal Issue: 2

DOI: 10.1007/s00406-014-0513-9

Abstract

The diacylglycerol kinase eta (DGKH) gene, first identified in a genome-wide association study, is one of the few replicated risk genes of bipolar affective disorder (BD). Following initial positive studies, it not only was found to be associated with BD but also implicated in the etiology of other psychiatric disorders featuring affective symptoms, rendering DGKH a cross-disorder risk gene. However, the (patho-)physiological role of the encoded enzyme is still elusive. In the present study, we investigated primarily the influence of a risk haplotype on amygdala volume in patients suffering from schizophrenia or BD as well as healthy controls and four single nucleotide polymorphisms conveying risk. There was a significant association of the DGKH risk haplotype with increased amygdala volume in BD, but not in schizophrenia or healthy controls. These findings add to the notion of a role of DGKH in the pathogenesis of BD.

Involved external institutions

Georg-August-Universität Göttingen DE Germany (DE) Ludwig-Maximilians-Universität (LMU) DE Germany (DE) Universitätsklinikum des Saarlandes (UKS) DE Germany (DE) Julius-Maximilians-Universität Würzburg DE Germany (DE)

How to cite

APA:

Kittel-Schneider, S., Wobrock, T., Scherk, H., Schneider-Axmann, T., Trost, S., Zilles, D.,... Reif, A. (2015). Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia. European archives of psychiatry and clinical neuroscience, 265(2), 127-136. https://doi.org/10.1007/s00406-014-0513-9

MLA:

Kittel-Schneider, S., et al. "Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia." European archives of psychiatry and clinical neuroscience 265.2 (2015): 127-136.

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