Generation of human induced pluripotent stem cell lines (hiPSC) from one bipolar disorder patient carrier of a DGKH risk haplotype and one non-risk-variant-carrier bipolar disorder patient
Palladino VS, Subrata NOC, Geburtig-Chiocchetti A, McNeill R, Hoffmann P, Reif A, Kittel-Schneider S (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 32
Pages Range: 104-109
DOI: 10.1016/j.scr.2018.09.008
Abstract
Fibroblasts were isolated from skin biopsies from two patients with bipolar I disorder. One patient was a 26 year old female carrying a risk haplotype in the DGKH (diacylglycerol kinase eta) gene and the other was a non-carrier 27 year old male. Patient fibroblasts were reprogrammed into human induced pluripotent stem cells (hiPSCs) by using a Sendai virus vector. DGKH-risk haplotype and non-risk haplotype hiPSCs showed expression of pluripotency markers and were able to differentiate into cells of the three germ layers. These cell models are useful to investigate the role of risk gene variants in bipolar disorder. Resource table. [Table presented]
Involved external institutions
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
Rheinische Friedrich-Wilhelms-Universität Bonn
Germany (DE)
Germany (DE)
Rheinische Friedrich-Wilhelms-Universität Bonn
Germany (DE)
How to cite
APA:
Palladino, V.S., Subrata, N.O.C., Geburtig-Chiocchetti, A., McNeill, R., Hoffmann, P., Reif, A., & Kittel-Schneider, S. (2018). Generation of human induced pluripotent stem cell lines (hiPSC) from one bipolar disorder patient carrier of a DGKH risk haplotype and one non-risk-variant-carrier bipolar disorder patient. Stem Cell Research, 32, 104-109. https://doi.org/10.1016/j.scr.2018.09.008
MLA:
Palladino, Viola Stella, et al. "Generation of human induced pluripotent stem cell lines (hiPSC) from one bipolar disorder patient carrier of a DGKH risk haplotype and one non-risk-variant-carrier bipolar disorder patient." Stem Cell Research 32 (2018): 104-109.
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