Comorbidity of ADHD and adult bipolar disorder: A systematic review and meta-analysis
Schiweck C, Arteaga-Henriquez G, Aichholzer M, Edwin Thanarajah S, Vargas-Cáceres S, Matura S, Grimm O, Haavik J, Kittel-Schneider S, Ramos-Quiroga JA, Faraone SV, Reif A (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Journal
Book Volume: 124
Pages Range: 100-123
DOI: 10.1016/j.neubiorev.2021.01.017
Abstract
Attention-deficit / hyperactivity disorder (ADHD) and Bipolar Disorder (BD) are common mental disorders with a high degree of comorbidity. However, no systematic review with meta-analysis has aimed to quantify the degree of comorbidity between both disorders. To this end we performed a systematic search of the literature in October 2020. In a meta-analysis of 71 studies with 646,766 participants from 18 countries, it was found that about one in thirteen adults with ADHD was also diagnosed with BD (7.95 %; 95 % CI: 5.31–11.06), and nearly one in six adults with BD had ADHD (17.11 %; 95 % CI: 13.05–21.59 %). Substantial heterogeneity of comorbidity rates was present, highlighting the importance of contextual factors: Heterogeneity could partially be explained by diagnostic system, sample size and geographical location. Age of BD onset occurred earlier in patients with comorbid ADHD (3.96 years; 95 % CI: 2.65–5.26, p < 0.001). Cultural and methodological differences deserve attention for evaluating diagnostic criteria and clinicians should be aware of the high comorbidity rates to prevent misdiagnosis and provide optimal care for both disorders.
Involved external institutions
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
Vall d'Hebron University Hospital / Hospital Universitari Vall d'Hebron
Spain (ES)
University of Bergen / Universitetet i Bergen
Norway (NO)
Universitätsklinikum Würzburg
Germany (DE)
State University of New York Upstate Medical University (SUNY)
United States (USA) (US)
Germany (DE)
Vall d'Hebron University Hospital / Hospital Universitari Vall d'Hebron
Spain (ES)
University of Bergen / Universitetet i Bergen
Norway (NO)
Universitätsklinikum Würzburg
Germany (DE)
State University of New York Upstate Medical University (SUNY)
United States (USA) (US)
How to cite
APA:
Schiweck, C., Arteaga-Henriquez, G., Aichholzer, M., Edwin Thanarajah, S., Vargas-Cáceres, S., Matura, S.,... Reif, A. (2021). Comorbidity of ADHD and adult bipolar disorder: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 124, 100-123. https://doi.org/10.1016/j.neubiorev.2021.01.017
MLA:
Schiweck, Carmen, et al. "Comorbidity of ADHD and adult bipolar disorder: A systematic review and meta-analysis." Neuroscience and Biobehavioral Reviews 124 (2021): 100-123.
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